Methods and means for preventing or treating inflammation or pruritis
OwnerJohanna G. H. Ruseler-van Embden, Leonarda M.C. van Lieshout +1inventors
InventorsJohanna G. H. Ruseler-van Embden, Leonarda M.C. van Lieshout, Jon D. Laman
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Abstract
The invention relates to methods and means for preventing, treating or reducing inflammation by inhibiting proteolytic activity, more specifically for preventing or reducing inflammations of skin or intestine. The invention provides a method for reducing or preventing an inflammation comprising subjecting a mammal to a treatment with at least one inhibitor which is capable of inhibiting proteolytic activity. In a preferred embodiment of the invention, said inhibitor is a plant product, such as potato juice or an inhibitor derived thereof.
Claims26
A skin care or topical pharmaceutical composition comprising at least one inhibitor capable of inhibiting proteolytic activity of a protease and a cosmetically or pharmaceutically acceptable vehicle, and wherein the inhibitor is derived from potato.
5 The skin care or topical pharmaceutical composition of claim 1, further comprising cosmetic adjuncts, pharmaceutical adjuvants or supplements.
A method of treating or preventing perineal, peri-anal or peristomal inflammation caused by proteolytic activity of feces in a subject, comprising:
- administering, topically, an inhibitor of proteolytic activity derived from a potato to the perineal, peri-anal or peristomal area of the subject, in unit dosage form containing about 0.1 to about 50 g of said inhibitor of proteolytic activity per day.
A diagnostic method for studying the effect of an inhibitor of proteolytic activity on inflammatory action of feces, the diagnostic method comprising:
- sterilizing feces;
- adding at least one proteolytic enzyme to said sterilized feces,
- placing a sample of said feces with proteolytic activity on the skin of a healthy subject;
- and
- monitoring the healthy subject skin for inflammatory action.
A cloth of woven material to which is chemically associated an inhibitor of proteolytic activity.
A method to derive protease inhibitors from plants or plant-parts, comprising:
- a) grinding the plant or plant parts to a pulp;
- b) separating the solids from the pulp to provide a juice of the plant or plant-part;
- c) coagulating bulk proteins in said juice, preferably by acidifying and heating of the juice;
- d) separating the coagulated proteins from the juice;
- e) adjusting the pH to a value of the juice of about 4.0;
- and
- f) isolating the protease inhibitors from the juice by precipitating the protease inhibitors with sodium polyphosphate.
Dependencies are inferred from the claim text.