Drug delivery system targeting to estrogen receptor over-expressed cells
AssigneeIndustrial Technology Research Institute
InventorsShyh-Dar Li, Ae-June Wang, Chung-Kung Lai
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Abstract
A vector for targeted delivery of drugs into estrogen receptors over-expressed cells is disclosed. The vector of the present invention is mainly about an active targeting delivery carrier which consists of a plurality of nanoparticles including: (i) a plurality of targeted moiety conjugated to the outer surface of the nanoparticles, the moiety being capable of binding with the estrogen receptor of a target cell, and (ii) bioactive agents encapsulated in the nanoparticles or forming complex with the nanoparticles. The targeted moiety of the present invention can also be conjugated to parent drugs for prodrug design.
Claims9
A drug delivery system for targeting estrogen over-expressed cells, comprising:
- a plurality of nanoparticles consisting of lipids, surfactants, charged peptides/proteins, or/and polymers;
- bioactive materials being encapsulated in or forming complex with said nanoparticles;
- and
- a plurality of ligand derivatives can be incorporated onto said nanoparticles and having a moiety capable of binding to the estrogen receptor of a target cell;
A compound of formula (II):
- 8
- wherein n is an integer bigger than 5.
Dependencies are inferred from the claim text.