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US 2004/0166159 A1Published application
Pharmaceutical dosage forms having immediate and controlled release properties that contain an aromatic amino acid decarboxylase inhibitor and levodopa
OwnerChien-Hsuan Han, Ann Hsu +1inventors
InventorsChien-Hsuan Han, Ann Hsu, Larry Hsu
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Abstract
The present invention relates generally to pharmaceutical dosage forms having immediate and controlled release properties that contain an aromatic amino acid decarboxylase (AAAD) inhibitor (such as carbidopa), levodopa, and optionally a cathecol-O-methyltransferase (COMT) inhibitor, for the treatment of medical conditions associated with reduced dopamine levels in a patient's brain.
Claims33
A pharmaceutical dosage form comprising an immediate release and a controlled release component,
- wherein said immediate release component and said controlled release component each comprises an AAAD inhibitor and levodopa in a ratio of from about 1:1 to about 1:50;
- wherein said immediate release component exhibits an in vitro dissolution profile comprising at least about 10% levodopa release after 15 minutes and at least about 60% levodopa release after 1 hour;
- and wherein said controlled release component exhibits an in vitro dissolution profile comprising from about 10% to about 60% levodopa release after 1 hour, from about 20% to about 80% levodopa release after 2 hours, and at least about 30% levodopa release after 6 hours.
Dependencies are inferred from the claim text.