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AssigneeWest Pharmaceutical Services Drug Delivery & Clinical Research Centre Limited
InventorsStanley Stewart Davis, Wu Lin, Fabio Bignotti, Paolo Ferruti
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PEG-chitosan conjugates comprising chitosan and polyethylene glycol moieties or derivatives thereof which are bonded together and their use in medicine is described. In one embodiment, the conjugate comprises a chitosan moiety or a derivative thereof and a polyethylene glycol moiety or a derivative thereof which are bonded together via the amino function on the chitosan by the use of an activated chitosan species. In another embodiment, the conjugate comprises a chitosan moiety or a derivative thereof and a polyethylene glycol moiety or a derivative thereof which are bonded together, the chitosan portion of the conjugate having a molecular weight in the range of from 10 kilodaltons to 1000 kilodaltons.
A composition for the controlled release of a drug comprising a polyethylene glycol- chitosan conjugate, wherein the polyethylene glycol-chitosan conjugate comprises a chitosan or chitosan derivative moiety and a polyethylene glycol or a polyethylene glycol derivative moiety, and the composition is formulated for delivery to a mucosal membrane.
A method for the preparation of a composition for the controlled release of a drug across a mucosal membrane comprising a polyethylene glycol-chitosan conjugate, the method comprising preparing the polyethylene glycol-chitosan conjugate by bonding the amino function of an activated chitosan species to a polyethylene glycol or polyethylene glycol derivative moiety.
Dependencies are inferred from the claim text.