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US 2004/0166157 A1Published application
Palatable controlled-released formulations for companion animals
AssigneePfizer Inc.
InventorAvinash G. Thombre
Life of this patent
Estimating the term…
Abstract
The invention pertains to chewable controlled-release multiparticulate pharmaceutical compositions for companion animals and method of making same.
Claims25
A palatable, chewable controlled release pharmaceutical composition for oral administration to a companion animal comprising:
- a therapeutically effective amount of a pharmaceutically active agent in controlled release multiparticulate form;
- and
- a palatability improving agent in an amount sufficient to make the pharmaceutical composition palatable to said companion animal.
A palatable, chewable controlled release pharmaceutical composition for oral administration to a companion animal comprising:
- a therapeutically effective amount of a pharmaceutically active agent in multiparticulate form comprising particles of said pharmaceutically active agent having an average particle size of up to about 5000 μm, said particles being coated with hydroxypropylmethyl cellulose, ethyl cellulose, Eudragit RL100, Eudragit RS100, mixtures of Eudragit RL100/RS 100, Eudragit NE30D, cellulose acetate butyrate, silicone, ethylcellulose dispersions, or combinations thereof, cellulose acetate phthalate, hydroxypropylmethyl cellulose phthalate, Eudragit L100-55, Eudragit S100 and mixtures of Eudragit L100-55/S10, or combinations thereof, said coating being present in an amount of about 5% to about 100% by weight of said pharmaceutical composition;
- and
- a palatability improving agent that is meat-derived, non-meat derived, fish-derived, non-fish derived, yeast or yeast hydrozalate, said palatability improving agent present in an amount of about 0.025% to about 99% by weight of said pharmaceutical composition.
24 A process for preparing a palatable, chewable controlled release pharmaceutical composition for oral administration to a companion animal comprising:
- preparing a therapeutically effective amount of a pharmaceutically active agent in the form of particles having an average particle size of up to about 5000 μm;
- coating said particles with a delayed release, sustained release or pulsatile release material in an amount of about 5% to about 100% by weight of the pharmaceutical composition;
- admixing a palatability improving agent to said coated particles in an amount of about 0.025% to about 99% by weight of said pharmaceutical composition;
- and
- forming said admixture into a shape suitable for oral administration to a companion animal.
2 more elements
Dependencies are inferred from the claim text.