Use of buckysome or carbon nanotube for drug delivery
OwnerAndreas Hirsch, Uri Sagman +1inventors
InventorsAndreas Hirsch, Uri Sagman, Stephen R. Wilson
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Abstract
Compositions and methods for administering a therapeutic agent to a mammal are disclosed. The compositions comprise either (i) vesicles comprising an amphiphilic substituted fullerene, wherein the therapeutic agent is present in the vesicle interior or between layers of the vesicle wall, (ii) a substituted fullerene, comprising a fullerene core and a functional moiety, wherein the therapeutic agent is associated with the substituted fullerene, or (iii) carbon nanotubes, wherein the therapeutic agent is covalently bonded to the carbon nanotubes.
Claims16
A method for administering a therapeutic molecule to a mammal, comprising:
- administering to the mammal an effective amount of a composition comprising a amphifullerene liposome comprising at least one amphifullerene, wherein the therapeutic molecule is located on the surface of the liposome, between layers of the liposome, entrapped within the liposome, or associated with a fullerene.
A amphifullerene liposome, comprising:
- an amphiphilic fullerene, and
- a therapeutic agent located on the surface of the liposome, between layers of the liposome, entrapped within the liposome, or associated with a fullerene.
A method of forming an amphifullerene liposome comprising a therapeutic agent, comprising:
- sonicating a solution of the amphifullerene liposome and the therapeutic agent.
A method of forming an amphifullerene liposome comprising a therapeutic agent, comprising:
- co-vaporizing a solution of the amphifullerene liposome and a solution of the therapeutic agent.
Dependencies are inferred from the claim text.