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US 2004/0166148 A1Published application
Transdermal therapeutic delivery systems with a butenolide
OwnerDirk Schenk, Elisabeth Meyer +2inventors
InventorsDirk Schenk, Elisabeth Meyer, Angelika Woess, Sarah McLeod
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Abstract
The invention concerns a transdermal therapeutic delivery system (TTDS) with butenolide.
Claims14
Transdermal therapeutic delivery system (TTDS) comprising one, two or more drugs and a butenolide.
Transdermal therapeutic delivery system (TTDS) comprising one, two or more drugs and a precursor of a butenolide, wherein the following drugs are excluded as drug:
- buprenorphin-base, desoxy peganin and an addition salt of levulinic acid and a morphin alkaloid of the following formula
- 2
- wherein
- R1 is H, C1-6-alkyl group or COCH3,
- R2 is H, OH, OCOCH3, ═O or ═CH2 and
- R3 is CH3, cyclopropyl, cyclobutyl or allyl, and wherein the C7/C8 linkage can be saturated or at N17 a nitroxyl group can be provided.
3 more elements
Transdermal therapeutic delivery system (TTDS) comprising one, two or more drugs and a precursor of a butenolide wherein the mole ratio of drug(s):
- precursor is of from 1:4.1 to 1:15 and especially 1:4.5 to 1:10.
Dependencies are inferred from the claim text.