Remedies for interstitial pneumonia, method of preparing animal model of said disease, and screening method using the same
OwnerTomoaki Hoshinoinventor
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Abstract
A remedy for interstitial pneumonia, comprising at least one, or two or more kinds of an interleukin 18 inhibitor and/or an interleukin 2 inhibitor as an active ingredient. A method of preparing an animal model of said disease, and a method of screening the remedy for interstitial pneumonia using the same. The remedy exerts a therapeutic effect by suppressing over-expression of an action of IL-18/IL-2 relating to the onset of interstitial pneumonia. The animal model is precisely capable of screening a drug, which can be expected to be clinically useful, because it resembles closely to the human clinical finding.
Claims31
A remedy for interstitial pneumonia, comprising at least one, or two or more kinds of an interleukin 18 inhibitor and/or an interleukin 2 inhibitor as an active ingredient.
A remedy for interstitial pneumonia, comprising an interleukin 18 inhibitor as an active ingredient.
A remedy for interstitial pneumonia, comprising an interleukin 2 inhibitor as an active ingredient.
A method of preparing an animal model of interstitial pneumonia, which comprises administering interleukin 18 and interleukin 2 to a rodent.
A composition, comprising at least one kind of an interleukin 18 inhibitor and/or an interleukin 2 inhibitor.
A method for preparing an animal model of interstitial pneumonia, which comprises the steps of:
- administering interleukin 18 and interleukin 2 to a rodent;
- and preparing an animal model of interstitial pneumonia.
A method for screening a remedy for interstitial pneumonia, which comprises the steps of:
- administering interleukin 18 and interleukin 2 to a rodent;
- preparing an animal model of interstitial pneumonia;
- and screening a remedy for interstitial pneumonia.
A method for preventing or treating interstitial pneumonia, comprising the step of administering to a patient who is subject to interstitial pneumonia an effective amount of at least one kind of an interleukin 18 inhibitor and/or an interleukin 2 inhibitor.
A method for preventing or treating interstitial pneumonia, comprising the step of administering to a patient who is subject to interstitial pneumonia an effective amount of an interleukin 18 inhibitor.
A method for preventing or treating interstitial pneumonia, comprising the step of administering to a patient who is subject to interstitial pneumonia an effective amount of an interleukin 2 inhibitor.
Dependencies are inferred from the claim text.