Adipose tissue-derived adult stem or stromal cells for the repair of articular cartilage fractures and uses thereof
AssigneeArtecel, Inc.
InventorsJon Kolkin, Jeffrey M. Gimble
Life of this patent
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Abstract
The invention provides cells, methods and compositions based upon the use of adipose tissue-derived adult stem cells in the repair of articular cartilage fractures or defects. The invention is useful in providing a treatment of articular cartilage fractures in a clinical setting.
Claims19
An isolated adipose tissue-derived adult stem cell differentiated to express at least one characteristic of a chondrocyte in combination with a viscous, biocompatible liquid material implanted into a host, wherein the host is in need of articular cartilage repair.
A composition comprising an isolated adipose tissue-derived adult stem cell differentiated to express at least one characteristic of a chondrocyte and implanted into host, a malleable, three dimensional matrix capable of filling an irregular cartilage defect and a solid phase, and a biocompatible material of sufficient structural integrity to serve as an anchor within the cancellous bone underlying the articular cartilage defect.
A method of treating an articular cartilage defect in a host comprising implanting an insolated adipose tissue-derived adult stem cell differentiated to express at least one characteristic of a chondrocyte.
A method of treating an articular cartilage defect in a host comprising implanting a composition comprising an insolated adipose tissue-derived adult stem cell differentiated to express at least one characteristic of a chondrocyte, a malleable, three dimensional matrix capable of filling an irregular cartilage defect and a solid phase, biocompatible material of sufficient structural integrity to serve as an anchor within the cancellous bone underlying the articular cartilage defect.
Dependencies are inferred from the claim text.