Methods for preventing GVHD
OwnerBruce R. Blazar, Matthew J. O'Shaughnessy +4inventors
InventorsBruce R. Blazar, Matthew J. O'Shaughnessy, Christine Vogtenhuber, Jonathan S. Serody, Albert S. Baldwin, Brian Poligone
Life of this patent
Estimating the term…
Abstract
Methods are provided for administering alloreactive T cells to transplant recipients such that the risk of graft-versus-host disease is reduced.
Claims20
A method for administering hematopoietic stem cells to a transplant recipient, said method comprising:
- (a) providing a donor hematopoictic stem cell composition comprising non-autologous T cells;
- (b) contacting said composition with an inhibitor of NF-κB activation to induce hyporesponsiveness of said T cells;
- and
- (c) administering said contacted composition to said recipient, wherein said contacted composition has a lower GVHD potential than a corresponding non-contacted composition.
A method for administering hematopoietic stem cells to a transplant recipient, said method comprising administering to said recipient (a) an inhibitor of NF-κB activation, and (b) a donor hematopoietic cell composition comprising alloreactive T cells.
A method of making a T cell tolerized to an alloantigen, said method comprising providing an isolated T cell, and contacting said isolated T cell with said alloantigen and an inhibitor of NF-κB activation.
A method for treating an autoimmune disorder in a subject, said method comprising identifying a subject having said autoimmune disorder, and administering to said subject a composition comprising a direct inhibitor of IKK.
A method for reducing transplant rejection, said method comprising administering to a transplant recipient a composition comprising a direct inhibitor of IKK, wherein said transplant is an organ transplant.
Dependencies are inferred from the claim text.