Compositions to reduce congestion and methods for application thereof to the nasal membrane

A composition for delivering an active substance to a nasal membrane, the composition comprising:

• about 75 to about 99.999 weight percent of a carrier comprising a thickener, wherein said thickener includes at least one of the following:
• glycerin, carrageenan, sugar, guar gum, methylcellulose, carbohydrate thickeners, aloe barbadensis gel, antiseptics, preservatives, permeation enhancers, sequestering agents, buffers, and emulsifiers;
• and
• about 0.000001 to about 10 weight percent an active substance,
• wherein the composition has a viscosity from about 3,000 centipoise to about 10,000 centipoise.

A composition for delivering an active substance to a nasal membrane, the composition comprising:

• about 90 to about 99.999 weight percent of a carrier and the carrier comprises about 0.5 to about 5.0 weight percent glycerin;
• about 0.001 to about 1.0 weight percent of a decongestant;
• about 0.0001 to about 0.1 weight percent of a thickener;
• about 0.001 to about 1.0 weight percent of a permeation enhancer;
• about 0.001 to about 1.0 weight percent of a preservative;
• and
• about 0.0001 to about 1.0 weight percent of a emulsifier,
• wherein the composition has a viscosity from about 4,000 centipoise to about 6,000 centipoise.

A system for delivering an active substance to the nasal membrane, the system comprising:

• a composition having about 90 to about 99.999 weight percent of a carrier and the carrier comprises about 0.5 to about 5.0 weight percent glycerin, and about 0.001 to about 5.0 weight percent of a decongestant, wherein the composition has a viscosity greater than about 2,500 centipoise;
• and
• a nasal applicator,
• wherein the composition is contained within the nasal applicator for dispensing an effective dosage into the nasal cavity of a patient.

A composition for application to a nasal membrane to reduce symptoms associated with allergies and the common cold, the composition comprising:

• about 90 to about 99.999 weight percent of a carrier;
• about 0.001 to about 5.0 weight percent of an active ingredient comprising oxymetazoline hydrochloride;
• and
• about 0.00001 to about 5.0 weight percent of a permeation enhancer comprising liposomes;
• wherein the composition has a viscosity configured to maintain said active ingredient in direct contact with a nasal membrane for an effective period of time.

A composition for application to a nasal membrane to reduce symptoms associated with allergies and the common cold, the composition comprising:

• about 90 to about 99.999 weight percent of a carrier;
• about 0.001 to about 5.0 weight percent of an active ingredient comprising oxymetazoline hydrochloride;
• about 0.00001 to about 5.0 weight percent of a permeation enhancer comprising liposomes;
• and
• about 0.000001 to about 1.0 weight percent of an aromatic substance comprising at least one of menthol or eucalyptus extract;
• wherein the composition has a viscosity configured to maintain said active ingredient in direct contact with a nasal membrane for an effective period of time.