Ablation therapy using chemical shift magnetic resonance imaging
OwnerDavid A. Roberts, Mark A. Rosen +1inventors
InventorsDavid A. Roberts, Mark A. Rosen, John S. Leigh JR.
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Abstract
The present invention relates to novel methods for direct visualization of the distribution of therapeutic agents, such as acetic acid, in the tissue of an animal, utilizing chemical shift magnetic resonance imaging (MRI). Said methods are particularly useful for percutaneous chemical ablation procedures to provide an optimal dosage of chemical ablation agent such as acetic acid to target tissues such as tumors, and for limiting damage to surrounding tissues.
Claims23
A method for mapping distribution of a therapeutic composition in the tissue of an animal, which comprises the steps of:
- (i) administering said therapeutic composition to the tissue of said animal, and
- (ii) directly visualizing the distribution of said therapeutic composition by chemical shift magnetic resonance imaging attuned to detect said therapeutic composition.
A method for mapping distribution of an acetic acid composition during a chemical ablation therapy procedure in a tumor in an animal, which comprises the steps of:
- (i) injecting said acetic acid composition into said tumor in an animal, and
- (ii) directly visualizing the distribution of said composition by chemical shift magnetic resonance imaging attuned to detect acetic acid resonance.
A method for treating an animal in need of chemical ablation therapy in a target tissue, comprising the steps of:
- (i) injecting a therapeutic composition into said target tissue of said animal;
- and
- (ii) directly visualizing the distribution of said therapeutic composition using chemical shift magnetic resonance imaging attuned to detect the resonance of said therapeutic composition.
Dependencies are inferred from the claim text.