Cobalamin conjugates useful as imaging and therapeutic agents
AssigneesMayo Foundation for Medical Education and Research, Regents of the University of Minnesota
InventorsDouglas A. Collins, Henricus P.C. Hogenkamp
Life of this patent
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Abstract
The invention provides detectably labeled cobalamin derivatives which are useful for medical treatment and diagnosis.
Claims69
A compound wherein a residue of a compound of formula I (FIG. 1) is linked to one or more peptide residues or amino acid residues wherein:
- 1) at least one of the peptide residues or the amino acid residues is linked to one or more chelating groups comprising one or more metallic radionuclides;
- or 2) at least one of the peptide residues or the amino acid residues comprises one or more non-metallic radionuclides;
- or a pharmaceutically acceptable salt thereof.
A compound wherein a residue of a compound of formula I is linked to one or more residues of the formula —[NHCH[(CH2)4NH2-DET]CO—]n-Q wherein Q is H, (C1-C14)alkyl, or a suitable carboxy protecting group;
- and DET is a chelating group residue comprising a metallic radionuclide and wherein n is between 2 and about 20;
- or a pharmaceutically acceptable salt thereof.
A compound wherein a residue of a compound of formula I is linked to one or more residues of the formula
- 5
- wherein each M is independently a non-metallic radionuclide;
- wherein each R is independently (C1-C14)alkyl, (C2-C14)alkenyl, (C2-C14)alkynyl, (C1-C14)alkoxy, hydroxy, cyano, nitro, halo, trifluoromethyl, N(Ra)(Rb), (C1-C]4)alkanoyl, (C2-C14)alkanoyloxy, (C6-C10)aryl, or (C3-C8)cycloalkyl wherein Ra and Rb are each independently H or (C1-C14)alkyl;
- Q is H, (C1-C14)alkyl, or a suitable amino protecting group;
- n is 2 to about 20;
- and wherein i is 1-5, j is 0-4 and i+j is ≦5;
- or a pharmaceutically acceptable salt thereof.
A compound wherein a residue of a compound of formula I is linked to a residue of a peptide which is linked to one or more chelating groups comprising a metallic radionuclide;
- or a pharmaceutically acceptable salt thereof.
A compound wherein a residue of a compound of formula I is linked to a residue of an amino acid which is linked to one or more chelating groups comprising a metallic radionuclide;
- or a pharmaceutically acceptable salt thereof.
A compound wherein a residue of a compound of formula I is linked to a residue of a peptide comprising one or more non-metallic radionuclides;
- or a pharmaceutically acceptable salt thereof.
A compound wherein a residue of a compound of formula I is linked to a residue of an amino acid comprising one or more non-metallic radionuclides;
- or a pharmaceutically acceptable salt thereof.
A compound wherein a residue of a compound of formula I (FIG. 1) is linked to one or more non-metallic radionuclides;
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.