Mass spectrometer and method of use
AssigneeHitachi, Ltd.
InventorsAkihiko Okumura, Izumi Waki
Life of this patent
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Abstract
Disclosed is a mass spectrometer combining an ion trap and a TOFMS non-coaxially, wherein ion trapping efficiency, mass resolution, and CID efficiency can be maximized. The present invention relates to the mass spectrometer combining the ion trap and the TOFMS non-coaxially, having a mass filter disposed between an ion source and an ion trap and a controller for controlling the gas pressure inside the ion trap and the gas pressure inside the mass filter independently, wherein the gas pressure inside the ion trap is set to the level higher than that inside the mass filter.
Claims20
A mass spectrometer comprising:
- an ion source;
- a 3D quadrupole ion trap for ejecting ions, after storing the ions generated by the ion source and stored for a certain period of time therein;
- a Time-Of-Flight Mass Spectrometer (TOFMS) for accelerating the ions ejected from the ion trap in a direction orthogonal to the direction of their travel and measuring the time-of-flight of the accelerated ions;
- and a mass filter, which is disposed between the ion source and the ion trap to control a first gas pressure inside the ion trap and a second gas pressure inside the mass filter independently.
A mass spectrometric method comprising:
- generating sample ions at an ion source;
- ejecting the ions after storing the ions generated in the ion source at a 3D quadrupole ion trap for a pre-set period of time;
- analyzing the masses of the ions and/or fragments generated by ion dissociation using a Time-of-Flight Mass Spectrometer, wherein the Time-of-Flight Mass Spectrometer accelerates the ions ejected from the ion trap in the direction orthogonal to the direction of their travel;
- and
- controlling the gas pressure inside the mass filter disposed between the ion source and controlling the gas pressure inside the ion trap, independently from each other.
A mass spectrometric method according to 11, further comprising:
- dissociating the ions stored in the ion trap through the mass filter to produce fragment ions therein.
A mass spectrometric method according to 11, further comprising:
- selecting a peak, which has intervals between neighboring peaks on a mass spectrum exceeding a value pre-determined based on an isolation resolution of the mass filter, among peaks on the mass spectrum;
- isolating the ion associated with the selected peak in the ion trap.
Dependencies are inferred from the claim text.