Factor VIII polypeptide
AssigneeIn2Gen Co., Ltd.
InventorsHun-Taek Kim, In-Young Song, Jae Won Choi, Jin-Wook Jang, Yong-Kook Kim, Ho Soon Lee, Yung-Jue Bang, Dae-Kee Kim
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Abstract
The application discloses Factor VIII polypeptides comprising internal deletions of amino acids within the area of residues 741 to 1689, wherein the thrombin cleavage sites at about 741 and about 1689 are present, and a site at about 1648 is not present, as compared to human Factor VIII.
Claims20
A Factor VIII polypeptide comprising an internal deletion of one or more amino acids between 1649 and 1688 fused to any amino acid sequence in B domain from about 741 to 782, with reference to full-length human Factor VIII amino acid sequence (SEQ ID NO:1).
Dependencies are inferred from the claim text.