Meg-4 protein
AssigneesToshio Miyata, Kiyoshi KuroKawa, Tokai University Educational System
InventorToshio Miyata
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Abstract
The present invention provides a DNA expressed at high frequency in mesangial cells and a protein (Meg-4) encoded by this DNA. These substances are useful in, for example, identifying mesangial cells and detecting abnormalities in mesangial cells. Moreover, the above protein would be helpful for clarification of the functions of mesangial cells and, in its turn, for clarification of the causes of diseases relating to mesangial cells. This protein is expectedly applicable to the treatment, diagnosis, and such of diseases relating to mesangial cells.
Claims21
A protein comprising the amino acid sequence of SEQ ID NO:
- 2, or a protein comprising the amino acid sequence of SEQ ID NO:
- 2 in which one or more amino acids are replaced, deleted, added, and/or inserted, and being functionally equivalent to the protein comprising the amino acid sequence of SEQ ID NO:
- 2.
A DNA hybridizing specifically with a DNA comprising the nucleotide sequence of SEQ ID NO:
- 1 or with the complementary strand thereof, the DNA having a chain length of at least 15 nucleotides.
A transgenic nonhuman vertebrate in which the expression level of a gene encoding Meg-4 is modified.
Dependencies are inferred from the claim text.