Modulation of alpha-methylacyl-CoA racemase expression
AssigneeIsis Pharmaceuticals, Inc.
InventorsKenneth W. Dobie, Ravi Jain
Life of this patent
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Abstract
Compounds, compositions and methods are provided for modulating the expression of alpha-methylacyl-CoA racemase. The compositions comprise oligonucleotides, targeted to nucleic acid encoding alpha-methylacyl-CoA racemase. Methods of using these compounds for modulation of alpha-methylacyl-CoA racemase expression and for diagnosis and treatment of disease associated with expression of alpha-methylacyl-CoA racemase are provided.
Claims24
A compound 8 to 80 nucleobases in length targeted to a nucleic acid molecule encoding alpha-methylacyl-CoA racemase, wherein said compound specifically hybridizes with said nucleic acid molecule encoding alpha-methylacyl-CoA racemase (SEQ ID NO:
- 4) and inhibits the expression of alpha-methylacyl-CoA racemase.
A method of screening for a modulator of alpha-methylacyl-CoA racemase, the method comprising the steps of:
- a. contacting a preferred target segment of a nucleic acid molecule encoding alpha-methylacyl-CoA racemase with one or more candidate modulators of alpha-methylacyl-CoA racemase, and
- b. identifying one or more modulators of alpha-methylacyl-CoA racemase expression which modulate the expression of alpha-methylacyl-CoA racemase.
A diagnostic method for identifying a disease state comprising identifying the presence of alpha-methylacyl-CoA racemase in a sample using at least one of the primers comprising SEQ ID NOs 5 or 6, or the probe comprising SEQ ID NO:
- 7.
Dependencies are inferred from the claim text.