Cyclopentane(ENE)heptenoic or heptanoic acids and derivatives thereof useful as therapeutic agents
AssigneeAllergan, Inc.
InventorRobert M. Burk
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Abstract
The invention relates to 7-[5-hydroxy-2-(hydroxyhydrocarbyl or heteroatom-substituted hydroxy hydrocarbyl)-3-hydroxycyclopentyl(enyl)]heptanoic or heptenoic acids and derivatives of said acids, wherein one or more of said hydroxy groups are replaced by an ether group. The compounds of the present invention are potent ocular hypotensives, and are particularly suitable for the management of glaucoma.
Claims3
A compound that is 7-[3α-5α-Dihydroxy-2β-(3α-methoxy-1E-octenyl)-cyclopentyl]-5Z-heptenamide or a pharmaceutically acceptable salt thereof.
A method of treating ocular hypertension or glaucoma which comprises applying to the eye an amount sufficient to treat ocular hypertension or glaucoma of 7-[3α-5α-Dihydroxy-2β-(3α-methoxy-1E-octenyl)-cyclopentyl]-5Z-heptenamide or a pharmaceutically acceptable salt thereof.
A pharmaceutical composition comprising a therapeutically effective amount of 7-[3α-5α-Dihydroxy-2β-(3α-methoxy-1E-octenyl)-cyclopentyl]-5Z-heptenamide or a pharmaceutically acceptable salt thereof and an ophthalmically acceptable pharmaceutical excipient.
Dependencies are inferred from the claim text.