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US 2004/0110965 A1Published application
Chiral ligand
AssigneeSumitomo Chemical Company, Limited
InventorsHeikki Hassila, Takayuki Higashii
Life of this patent
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Abstract
There is disclosed a chiral phosphine compound of formula (1): 1 The chiral phosphine compound is suitably used to produce a transition metal complex that is useful as an asymmetric reaction catalyst.
Claims7
A chiral phosphine compound of formula (1):
- 19
- wherein R1 and R2 independently represent
- an aryl or heteroaryl group, which may be substituted,
- a saturated hydrocarbon group, which may be substituted, and
- Ar group independently represents
- a heteroaryl group, which may be substituted,
- an aryloxy group, which may be substituted, or
- Ar groups on the same phosphorous atom are bonded to form an arylene, heteroarylene or alkylene group, which may be substituted, and
- * represents an asymmetric carbon atom.
6 more elements
A process for producing a chiral phosphine compound of formula (1):
- 21
- wherein R1 and R2 independently represent
- an aryl or heteroaryl group, which may be substituted,
- a saturated hydrocarbon group, which may be substituted, and
- Ar group independently represents
- an aryl or heteroaryl group, which may be substituted,
- an aryloxy group, which may be substituted,
- a saturated hydrocarbon group, which may be substituted, or
- Ar groups on the same phosphorus atom are bonded to form an arylene, heteroarylene or alkylene group, which may be substituted, and
- * represents an asymmetric carbon atom, which comprises reacting
- an optically active azetidine alcohol compound of formula (2):
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- wherein R1, R2 and * represent the same as defined above, with a phosphine of formula (3):
- XPAr2 (3)
- wherein X represents a halogen atom, and Ar represents the same as defined above.
12 more elements
An optically active azetidine alcohol of formula (4):
- 23
- wherein R1 and R2 independently represent
- a saturated hydrocarbon group, which may be substituted, and
- * represents an asymmetric carbon atom.
1 more element
Dependencies are inferred from the claim text.