N-4-piperidinyl compounds as ccr5 modulators

A compound of formula (I):

• 40
• wherein:
• R1 is C3-7 cycloalkyl, C4-7 cycloalkyl fused to a phenyl ring, C5-7 cycloalkenyl, heterocyclyl (itself optionally substituted by oxo or C1-4 alkyl), C1-8 alkyl (substituted by C3-6 cycloalkyl, C5-6 cycloalkenyl, S(O)pR7 or COR8), C2-8 alkenyl or C2-8 alkynyl;
• R2 is optionally substituted phenyl, optionally substituted heteroaryl or cycloalkyl;
• R2a, R4 and R4a are, independently, hydrogen or C1-4 alkyl;
• R3 and R3a are, independently, hydrogen or C1-4 alkyl or C1-4 alkoxy;
• R5 is hydrogen, C1-4 alkyl (optionally substituted by halogen, hydroxy, C1-4 alkoxy, C3-7 cycloalkyl, SH, C1-4 alkylthio, cyano or S(O)q(C1-4 alkyl)), C3-4 alkenyl, C3-4 alkynyl or C3-7 cycloalkyl;
• R6 is phenyl, heteroaryl, phenylNH, heteroarylNH, phenyl(C1-2)alkyl, heteroaryl(C1-2 )alkyl, phenyl(C1-2 alkyl)NH or heteroaryl(C1-2 alkyl)NH;
• R7 and R8 are, independently, C1-4 alkyl;
• wherein the phenyl and heteroaryl rings of any of the foregoing are independently optionally substituted by halo, cyano, nitro, hydroxy, C1-4 alkyl, C1-4 alkoxy, S(O)mC1-4 alkyl, S(O)2NR9R10, NHS(O)2(C1-4 alkyl), NH2, NH(C1-4 alkyl), N(C1-4 alkyl)2, NHC(O)NH2, C(O)NH2, C(O)NH(C1-4 alkyl), NHC(O)(C1-4 alkyl), CO2H, CO2(C1-4 alkyl), C(O)(C1-4 alkyl), CF3, CHF2, CH2F, CH2CF3 or OCF3;
• R9 and R10 are, independently, hydrogen or C1-4 alkyl, or together with a nitrogen or oxygen atom, may join to form a 5- or 6-membered ring which is optionally substituted with C1-4 alkyl, C(O)H or C(O)(C1-4 alkyl);
• m, p and q are, independently, 0, 1 or 2;
• provided that when heterocyclyl contains a one heteroatom and that heteroatom is nitrogen, then the heterocyclyl ring is not N-linked to the remainder of the structure of formula (I);
• and provided that when R1 is cyclobutyl or tetrahydropyran, R2 is optionally substituted phenyl, R3 is hydrogen or alkoxy and R6 is benzyl (optionally substituted by alkoxy) or pyridinylmethyl, then R2a, R3a, R4, R4a and R5 are not all hydrogen;
• or a pharmaceutically acceptable salt thereof or a solvate thereof.