Substituted 2-carba-3,5-dicyano-4-aryl-6-aminopyridines and the use of the same as selective ligands of the adenosine receptor

A compound of the formula (I)

• 26
• in which
• R1, R2 and R3 independently of one another represent (C1-C8)-alkyl which may be substituted up to three times by hydroxyl, (C1-C4)-alkoxy, (C3-C7)-cycloalkyl, (C2-C4)-alkenyl, (C2-C4)-alkynyl, halogen or (C6-C10)-aryloxy, (C6-C10)-aryl which may be substituted up to three times by halogen, nitro, (C1-C4)-alkoxy, carboxyl, (C1-C4)-alkoxycarbonyl or mono- or di-(C1-C4)-alkylamino, (C1-C8)-alkoxy which may be substituted by hydroxyl, (C1-C4)-alkoxy, (C3-C7)-cycloalkyl, (C2-C4)-alkenyl, (C6-C10)-aryl, 5- or 6-membered heteroaryl having up to three heteroatoms from the group consisting of N, O and/or S, (C6-C10-aryloxy, halogen, cyano, (C1-C4)-alkoxycarbonyl, (C1-C4)-alkanoyloxy, amino or mono- or di-(C1-C4)-alkylamino, hydrogen, hydroxyl, halogen, nitro, cyano or —NH—C(O)—R7,
• in which
• R7 represents (C1-C8)-alkyl which may be substituted by hydroxyl or (C1-C4)-alkoxy, (C3-C7)-cycloalkyl or (C6-C10)-aryl which may be substituted up to three times by, independently of one another, by halogen, nitro, (C1-C4)-alkoxy, carboxyl, (C1-C4)-alkoxycarbonyl or mono- or di-(C1-C4)-alkylamino,
• or
• R1 and R2 are attached to adjacent phenyl ring atoms and, together with the two ring carbon atoms, form a 5- to 7-membered saturated or partially unsaturated heterocycle having one or two heteroatoms from the group consisting of N, O and/or S which may be substituted by (C1-C4)-alkyl or oxo,
• R4 represents hydrogen, (C1-C8)-alkyl which may be substituted by hydroxyl, (C1-C4)-alkoxy, (C3-C7)-cycloalkyl, (C6-C10)-aryl, 5- or 6-membered saturated or partially saturated heterocyclyl having up to three heteroatoms from the group consisting of N, O and/or S or 5- to 10-membered heteroaryl having up to three heteroatoms from the group consisting of N, O and/or S, or (C3-C7)-cycloalkyl which may be substituted by hydroxyl or (C1-C8)-alkyl,
• R5 represents (C1-C4)-alkyl or (C1-C4)-alkoxy which may be mono- or disubstituted, independently of one another, by hydroxyl, (C1-C4)-alkoxy, (C3-C7)-cycloalkyl, (C6-C10)-aryl or 5- to 10-membered heteroaryl having up to three heteroatoms from the group consisting of N, O and/or S, where aryl and heteroaryl for their part may be substituted by halogen, (C1-C4)-alkyl, (C1-C4)-alkoxy, amino, mono- or di-(C1-C4)-alkylamino, nitro, cyano, trifluoromethyl or hydroxyl, or (C2-C4)-alkenyl,
• R6 represents (C1-C8)-alkyl which may be substituted by hydroxyl, (C1-C4)-alkoxy, (C3-C7)-cycloalkyl, (C2-C4)-alkenyl, —CO—O—R8, (C6-C10)-aryl or 5- to 10-membered heteroaryl having up to three heteroatoms from the group consisting of N, O and/or S where aryl and heteroaryl for their part may be substituted by halogen, (C1-C4)-alkyl, (C1-C4)-alkoxy, amino, mono- or di-(C1-C4)-alkylamino, nitro, cyano, trifluoromethyl or hydroxyl, (C3-C7)-cycloalkyl or —CO—O—R8,
• in which
• R8 represents hydrogen, (C1-C8)-alkyl which may be substituted by hydroxyl or (C1-C4)-alkoxy, (C3-C7)-cycloalkyl or (C6-C10)-aryl which may be substituted up to three times, independently of one another, by halogen, nitro, (C1-C4)-alkoxy, carboxyl, (C1-C4)-alkoxycarbonyl or mono- or di-(C1-C4)-alkylamino,
• or
• R5 and R6 together with the carbon atom to which they are attached form a 3- to 7-membered saturated or partially unsaturated ring which may contain one or two heteroatoms from the group consisting of N, O and/or S in the ring and which may be mono- to trisubstituted, independently of one another, by oxo, fluorine, chlorine, bromine, hydroxyl, (C1-C6)-alkyl or (C1-C6)-alkoxy,
• or a salt, a hydrate, a hydrate of a salt or a solvate thereof.