Vla-4 inhibitors

A compound represented by the following formula (I):

• 808
• (wherein, W represents WA—A1—WB—
• (in which, WA represents a substituted or unsubstituted aryl group or a substituted or unsubstituted monovalent heterocyclic group, A1 represents —NR1—, a single bond, —C(O)—, —C(O)NR1—, a substituted or unsubstituted vinylene group, an ethynylene group, —CR1aR1b—, O—, —CR1a═CR1b—C(O)NR1— or —CR1a═CR1b═C(O)—(in which, R1 represents a hydrogen atom or a lower alkyl group, and R1a and R1b each independently represents a hydrogen atom or a lower alkyl group), and WB represents a substituted or unsubstituted arylene group or a substituted or unsubstituted divalent heterocyclic group);
• R represents a single bond, —NH—, —OCH2—, an alkenylene group or —(CH2)n— (in which, n stands for 1 or 2);
• X represents —C(O)—, —CH2— or —S(O)2—, and
• M represents the following formula (iii), (iv) or (v):
• 809
• represents a divalent 4-, 5-, 6- or 7-membered heterocyclic group (in which the nitrogen atom is bonded to X and Q represents a carbon, sulfur, oxygen or nitrogen atom), R11, R12 and R13 each independently represents a hydrogen atom, a hydroxyl group, an amino group, a halogen atom, a cyano group, a carboxyl group, an alkoxycarbonyl group, a carbamoyl group, a substituted or unsubstituted mono- or dialkylaminocarbonyl group, a substituted or unsubstituted alkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted heteroaryl group, a substituted or unsubstituted alkoxy group, a substituted or unsubstituted mono- or dialkylamino group, a substituted or unsubstituted cycloalkylamino group, a substituted or unsubstituted alkylsulfonylamino group, a substituted or unsubstituted arylsulfonylamino group, a substituted or unsubstituted aryloxy group, a substituted or unsubstituted heteroaryloxy group, a substituted or unsubstituted benzyloxy group, a substituted or unsubstituted alkylthio group, a substituted or unsubstituted cycloalkylthio group, a substituted or unsubstituted arylthio group, a substituted or unsubstituted alkylsulfonyl group, a substituted or unsubstituted cycloalkylsulfonyl group, or a substituted or unsubstituted arylsulfonyl group, or R11 and R12 or R12 and R13 may be coupled to form, together with the atom constituting the heterocyclic group to which R11 to R13 are bonded, a 3 to 7-membered cyclic hydrocarbon or heterocycle (which may have, on the ring thereof, 1 to 3 substituents selected from a hydroxyl group, halogen atoms, an amino group, alkyl groups, alkoxy groups, aryl groups, aryloxy groups, alkylamino groups, a benzyloxy group and heteroaryl groups), R14 represents a hydrogen atom or a substituted or unsubstituted lower alkyl group, Y represents a single bond, —C(O)—, —C(O)NH—, or a linear or branched divalent aliphatic C1-12 hydrocarbon group which may have a C3-6 spiro ring or may have one or more carbon atoms substituted with —O—, —S—, —S(O)2—, —C(O)— or —NY1— (in which, Y1 represents a hydrogen atom or a lower alkyl group), Z represents a substituted or unsubstituted arylene group, a substituted or unsubstituted heteroarylene group or a substituted or unsubstituted cycloalkylene group, A2 represents a single bond, an alkenylene group, an alkynylene group, —(CH2)t— or —O(CH2)v— (in which, t stands for 1, 2 or 3 and v stands for 0, 1, 2 or 3), and R10 represents a hydroxyl or a lower alkoxy group),
• 810
• represents a divalent 4-, 5-, 6- or 7-membered heterocyclic group (in which the nitrogen atom is bonded to X, and Q1 represents a carbon, sulfur, oxygen or nitrogen atom), R15 and R16 each independently represents a hydrogen atom, a hydroxyl group, a halogen atom, a substituted or unsubstituted alkyl group or an alkoxy group, R16a represents a hydrogen atom or a substituted or unsubstituted alkyl group, y3 represents —O—, —S—, —S(O)2—, —(CH2)fO— or —NY4— (in which f stands for 1, 2 or 3 and Y4 represents a hydrogen atom or a lower alkyl group), Z1 represents a substituted or unsubstituted arylene group, a substituted or unsubstituted heteroarylene group or a substituted or unsubstituted cycloalkylene group, A3 represents a single bond, an alkenylene group, an alkynylene group or —(CH2)e— (in which e stands for 1, 2 or 3), and R17 represents a hydroxyl group or a lower alkoxy group),
• 811
• (in which, R18 represents —NR20— (in which R20 represents a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted cycloalkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted benzyl group, a substituted or unsubstituted lower alkenyl group or a substituted or unsubstituted alkynyl group), Z2 represents a linear or branched divalent aliphatic C1-12 hydrocarbon group which may have a C3-6 spiro ring, may have one or more carbon atoms substituted with a divalent C3-8 cycloalkylene group or may have one or more carbon atoms substituted with —O—, —S—, —S(O) 2—, —C (O)— or —NR 21— (in which, R21 represents a hydrogen atom or a substituted or unsubstituted lower alkyl group), Q2 represents a single bond, a substituted or unsubstituted arylene group, a substituted or unsubstituted heteroarylene group or a substituted or unsubstituted cycloalkylene group, L stands for a single bond, a substituted or unsubstituted lower alkylene group or a substituted or unsubstituted lower alkenylene group, or R19 represents a hydroxyl or a lower alkoxy group));
• or salt thereof.