Complementary DNAs encoding proteins with signal peptides
AssigneeGenset S.A.
InventorsJean-Baptiste Dumas Milne Edwards, Lydie Bougueleret, Severin Jobert, Catherine Clusel, Aymeric Duclert
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Abstract
The sequences of cDNAs encoding secreted proteins are disclosed. The cDNAs can be used to express secreted proteins or fragments thereof or to obtain antibodies capable of specifically binding to the secreted proteins. The cDNAs may also be used in diagnostic, forensic, gene therapy, and chromosome mapping procedures. The cDNAs may also be used to design expression vectors and secretion vectors.
Claims13
An isolated polynucleotide, comprising a nucleic acid sequence selected from the group consisting of:
- a) a polynucleotide of any one of SEQ ID NOs:
- 1-405, or of a human cDNA of a deposited clone, encoding at least any single integer from 6 to 500 amino acids of any one of SEQ ID NOs:
- 406-810,
- b) a polynucleotide of any one of SEQ ID NOs:
- 1-405, or of a human cDNA of a deposited clone, encoding the signal peptide sequence of any one of SEQ ID NOs:
- 406-810,
- c) a polynucleotide of any one of SEQ ID NOs:
- 1-405, or of a human cDNA of a deposited clone, encoding a mature polypeptide sequence of any one of SEQ ID NOs:
- 406-810,
- d) a polynucleotide of any one of SEQ ID NOs:
- 1-405, or of a human cDNA of a deposited clone, encoding a full length polypeptide sequence of any one of SEQ ID NOs:
- 406-810,
- e) a polynucleotide of any one of SEQ ID NOs:
- 1-405, or of a human cDNA of a deposited clone, encoding a polypeptide sequence of a biologically active fragment of any one of SEQ ID NOs:
- 406-810,
- f) a polynucleotide encoding a polypeptide sequence of at least any single integer from 6 to 500 amino acids of any one of SEQ ID NOs:
- 406-810 or of a polypeptide encoded by a human cDNA of a deposited clone,
- g) a polynucleotide encoding a polypeptide sequence of a signal peptide of any one of SEQ ID NOs:
- 406-810 or of a signal peptide encoded by a human cDNA of a deposited clone,
- h) a polynucleotide encoding a polypeptide sequence of a mature polypeptide of any one of SEQ ID NOs:
- 406-810 or of a mature polypeptide encoded by a human cDNA of a deposited clone,
- i) a polynucleotide encoding a polypeptide sequence of a full length polypeptide of any one of SEQ ID NOs:
- 406-810 or of a mature polypeptide encoded by a human cDNA of a deposited clone,
- j) a polynucleotide encoding a polypeptide sequence of a biologically polypeptide of any one of SEQ ID NOs:
- 406-810, or of a biologically polypeptide encoded by a human cDNA of a deposited clone,
- k) a polynucleotide of any one of a) through j) further comprising an expression vector,
- l) a host cell recombinant for a polynucleotide of a) through k) above,
- m) a non-human transgenic animal comprising the host cell of k),
- n) a polynucleotide of a) through j) further comprising a physiologically acceptable carrier.
A polypeptide comprising an amino acid sequence selected from the group consisting of:
- a) any single integer from 6 to 500 amino acids of any one of SEQ ID NOs:
- 406-810 or of a polypeptide encoded by a human cDNA of a deposited clone;
- b) a signal peptide sequence of any one of SEQ ID NOs:
- 406-810 or encoded by a human cDNA of a deposited clone;
- c) a mature polypeptide sequence of any one of SEQ ID NOs:
- 406-810 or encoded by a human cDNA of a deposited clone;
- d) a full length polypeptide sequence of any one of SEQ ID NOs:
- 406-810 or encoded by a human cDNA of a deposited clone;
- e) a polypeptide of a) through d) further comprising a physiologically acceptable carrier.
Dependencies are inferred from the claim text.