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OwnerRajesh Bhikhu Parekh, Herath Mudiyanselage Athula Chandrasiri Herath +3inventors
InventorsRajesh Bhikhu Parekh, Herath Mudiyanselage Athula Chandrasiri Herath, Christian Rohlff, Jonathan Alexander Terrett, Kerry Louise Tyson
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The present invention provides methods and compositions for screening, diagnosis and prognosis of Schizophrenia, for monitoring the effectiveness of Schizophrenia treatment, identifying patients most likely to respond to a particular therapeutic treatment and for drug development. Schizophrenia-Associated Features (SFs), detectable by two-dimensional electrophoresis of cerebrospinal fluid, serum or plasma are described. The invention further provides Schizophrenia-Associated Protein Isoforms (SPIs) detectable in cerebrospinal fluid, serum or plasma, preparations comprising isolated SPIs, antibodies immunospecific for SPIs, and kits comprising the aforesaid.
An isolated nucleic acid molecule that hybridizes under highly stringent conditions or moderately stringent conditions to one or both of the following nucleic acid sequences:
An isolated nucleic acid molecule that hybridizes under highly stringent conditions or moderately stringent conditions to the amino acid sequence listed in FIG. 2B.
A preparation comprising an isolated human protein, said protein comprising one or more of the following sequences:
Dependencies are inferred from the claim text.