Xin-related proteins
OwnerMichael G. Walker, Randi E. Krasnow +1inventors
InventorsMichael G. Walker, Randi E. Krasnow, Mariah R. Baughn
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Abstract
The invention provides mammalian cDNAs which encode Xin-related proteins. It also provides for the use of the cDNAs, fragments, and complements thereof and of the encoded proteins, portions thereof and antibodies thereto for diagnosis and treatment of cardiac and skeletal muscle disorders, particularly hypertrophic cardiomyopathy, and for monitoring cardiac and skeletal muscle morphogenesis and development. The invention additionally provides expression vectors and host cells for the production of the proteins.
Claims20
An isolated mammalian cDNA or a fragment thereof encoding a mammalian protein or a portion thereof selected from:
- a) an amino acid sequence of SEQ ID NO:1 and SEQ ID NO:2;
- b) an antigenic epitope of SEQ ID NO:1 or SEQ ID NO:2;
- c) an oligopeptide of SEQ ID NO:1 or SEQ ID NO:2;
- and
- d) a biologically active portion of SEQ ID NO;1 or SEQ ID NO:2.
An isolated mammalian cDNA encoding a mammalian protein of SEQ ID NO:1 or SEQ ID NO:2.
An isolated mammalian cDNA or the complement thereof selected from:
- a) a nucleic acid sequence of SEQ ID NO:3 and SEQ ID NO:20;
- b) a fragment selected from SEQ ID NOs:4-19 and SEQ ID NOs:21-33;
- c) an oligonucleotide of SEQ ID NOs:3-33.
A purified mammalian protein or a portion thereof selected from:
- a) an amino acid sequence of SEQ ID NO:1 and SEQ ID NO:2;
- b) an antigenic epitope of SEQ ID NO:1 or SEQ ID NO:2;
- c) an oligopeptide of SEQ ID NO:1 or SEQ ID NO:2;
- and
- d) a biologically active portion of SEQ ID NO:1 or SEQ ID NO:2.
Dependencies are inferred from the claim text.