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US 2004/0110936 A1Published application
N-substituted pyrazole-O-glycoside derivatives and therapeutic agent for diabetes containing the same
AssigneeAjinomoto Co., Inc.
InventorsKoji Ohsumi, Hiroyuki Matsueda, Toshihiro Hatanaka, Nozomu Ishida, Yoko Kageyama, Katsumi Maezono, Nobuo Kondo
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Abstract
The present invention relates to pyrazole derivatives represented by the following formulas and analogues thereof, which can be used for a therapeutic agent for diabetes. 1
Claims20
A pyrazole derivative represented by general formula (1A) or (1B), or pharmaceutically acceptable salt thereof:
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- wherein X represents β-D-glucopyranosyl group, wherein one or more hydroxyl groups may be acylated;
- Y represents a lower alkyl group or a perfluoro lower alkyl group;
- Z represents a cyclic alkyl group which may have a substituent(s), a cyclic unsaturated alkyl group which may have a substituent(s), a lower alkyl group having a cyclic alkyl group which may have a substituent(s), or a lower alkyl group having a cyclic unsaturated alkyl group which may have a substituent(s);
- R1 to R5 may be the same or different and each represent a hydrogen atom, a lower alkyl group, a perfluoro lower alkyl group, a lower alkoxyl group, a perfluoro lower alkoxyl group, a lower alkylthio group, a perfluoro lower alkylthio group, a lower alkylamino group, a halogeno group, a lower alkanoyl group, an alkenyl group, a cyclic alkenyl group, an alkynyl group, a phenyl group which may have a substituent(s), or a lower alkoxycarbonyl group;
- and n is an integer of 0 to 3.
3 more elements
A pyrazole-O-glycoside derivative represented by formula (I) or pharmaceutically acceptable salt thereof:
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- wherein X′ represents β-D-glucopyranosyl group, wherein one or more hydroxyl groups may be acylated;
- Y′ represents a hydrogen atom, a lower alkyl group, a fluoro lower alkyl group or a perfluoro lower alkyl group;
- Z′ represents a halo lower alkyl group;
- and R1′ to R5′ may be the same or different and each represent a hydrogen atom, a halogeno group, a lower alkyl group, a halo lower alkyl group, a perfluoro lower alkyl group, a lower alkoxyl group, a perfluoro lower alkoxyl group, a lower alkylthio group, a perfluoro lower alkylthio group, a lower alkylamino group, a lower alkanoyl group, a lower alkenyl group, or a lower alkynyl group.
2 more elements
Dependencies are inferred from the claim text.