Cytokine zalpha11 ligand
AssigneeZymoGenetics, Inc.
InventorsJulia E. Novak, Scott R. Presnell, Cindy A. Sprecher, Donald C. Foster, Richard D. Holly, Jane A. Gross, Janet V. Johnston, Andrew J. Nelson, Stacey R. Dillon, Angela K. Hammond
Life of this patent
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Abstract
The present invention relates to zalpha11 Ligand polynucleotide and polypeptide molecules. The zalpha11 Ligand is a novel cytokine. The polypeptides may be used within methods for stimulating the proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
Claims47
An isolated polypeptide comprising a sequence of amino acid residues that is at least 90% identical to residues 41 (Gln) to 148 (Ile) as shown in SEQ ID NO:2.
An isolated polypeptide comprising a sequence of amino acid residues that is at least 95% identical to residues 41 (Gln) to 148 (Ile) as shown in SEQ ID NO:2.
An isolated polypeptide comprising a sequence of amino acid residues that is identical to residues 41 (Gln) to 148 (Ile) as shown in SEQ ID NO:2.
The isolated polypeptides of claims (1), (2), or (3), wherein the polypeptide binds the zalpha11 Ligand receptor as shown in SEQ ID NO:115.
An isolated polypeptide comprising a sequence of amino acid residues that is at least 90% identical to residues 32 (Gln) to 148 (Ile) as shown in SEQ ID NO:2.
An isolated polypeptide comprising a sequence of amino acid residues that is at least 95% identical to residues 32 (Gln) to 162 (Ser) as shown in SEQ ID NO:2.
An isolated polypeptide comprising a sequence of amino acid residues as shown in SEQ ID NO:2 from residues 32 (Gln) to 162 (Ser), wherein the polypeptide has an N-terminal Met.
A pharmaceutical composition comprising a polypeptide comprising a sequence of amino acid residues that is at least 80% identical to residues 32 (Gln) to 162 (Ser) as shown in SEQ ID NO:2, a pharmaceutically acceptable vehicle.
A pharmaceutical composition comprising a polypeptide comprising a sequence of amino acid residues that is at least 90% identical to residues 32 (Gln) to 162 (Ser) as shown in SEQ ID NO:2, a pharmaceutically acceptable vehicle.
A pharmaceutical composition comprising a polypeptide comprising a sequence of amino acid residues that is at least 95% identical to residues 32 (Gln) to 162 (Ser) as shown in SEQ ID NO:2, a pharmaceutically acceptable vehicle.
A pharmaceutical composition comprising a polypeptide comprising a sequence of amino acid residues from residues 32 (Gln) to 162 (Ser) as shown in SEQ ID NO:2, a pharmaceutically acceptable vehicle.
A method of treating cancer in a mammal comprising administering to a mammal in need thereof a therapeutically effective dose of a polypeptide as shown in SEQ ID NO:2 from amino acid residue 32 to residue 162, wherein the treatment results in a clinically significant improvement in the mammal.
A method of stimulating an immune response in a mammal with melanoma comprising administering a therapeutically effective amount of a polypeptide comprising an amino acid sequence as shown in SEQ ID NO:2 from amino acid residue 32 to amino acid residue 162 to the mammal, wherein the stimulation of the immune response results in enhancing an anti tumor activity.
A method of stimulating an immune response in a mammal with melanoma comprising administering a therapeutically effective amount of a polypeptide comprising an amino acid sequence as shown in SEQ ID NO:2 from amino acid residue 32 to amino acid residue 162 to the mammal, wherein the stimulation of the immune response results in an increased capacity of the immune cells to react with the tumor.
A method of stimulating an immune response in a mammal bearing a tumor comprising administering a therapeutically effect amount of a polynucleotide encoding a polypeptide comprising an amino acid sequence as shown in SEQ ID NO:2 from amino acid residue 32 to residue 162, wherein the stimulation results enhanced tumor activity.
A method of stimulating an immune response in a mammal bearing a tumor comprising administering a therapeutically effect amount of a polynucleotide encoding a polypeptide comprising an amino acid sequence as shown in SEQ ID NO:2 from amino acid residue 32 to residue 162, wherein the stimulation of the immune response results in an increased capacity of the immune cells to react with the tumor.
A method of stimulating an immune response in a mammal in need thereof comprising administering a therapeutically effect amount of a polypeptide as shown in SEQ ID NO:2 from amino acid residue 32 to 162, wherein stimulation of the immune response results in clinically significant improvement in the mammal.
A method of stimulating an immune response in a mammal comprising administering a pharmaceutical composition comprising a therapeutically effective amount of an antigen in a pharmaceutically acceptable vehicle and administering a pharmaceutical composition comprising a therapeutic amount of a polypeptide as shown in SEQ ID NO:2 from amino acid residue 32 to residue 162 in a pharmaceutically acceptable vehicle to the mammal.
A method of stimulating an immune response in a mammal comprising administering a pharmaceutical composition comprising a therapeutic amount of an antigen and a therapeutic amount of a polypeptide as shown in SEQ ID NO:2 from amino acid residue 32 (Gln) to residue 162 (Ser) in a pharmaceutically acceptable vehicle.
An isolated polynucleotide comprising a sequence of nucleotides that encode amino acid residues that are at least 90% identical to residues 41 (Gln) to 148 (Ile) as shown in SEQ ID NO:2, wherein the polynucleotide encodes a polypeptide that binds a receptor as shown in SEQ ID NO:115.
An isolated polynucleotide comprising a sequence of nucleotides that encode amino acid residues that are at least 95% identical to residues 41 (Gln) to 148 (Ile) as shown in SEQ ID NO:2, wherein the polynucleotide encodes a polypeptide that binds a receptor as shown in SEQ ID NO:115.
An isolated polynucleotide comprising a sequence nucleotides encoding amino acid residues that are at least 90% identical to residues 32 (Gln) to 148 (Ile) as shown in SEQ If) NO:2, wherein the polynucleotide encodes a polypeptide that binds a receptor as shown in SEQ ID NO:115.
An isolated polynucleotide comprising a sequence nucleotides that encode amino acid residues that are at least 95% identical to residues 32 (Gln) to 148 (Ile) as shown in SEQ ID NO:2, wherein the polynucleotide encodes a polypeptide that binds a receptor as shown in SEQ ID NO:115.
A pharmaceutical composition comprising a polynucleotide encoding a polypeptide comprising a sequence of amino acid residues from residues 32 (Gln) to 162 (Ser) as shown in SEQ ID NO:2, in a pharmaceutically acceptable vehicle.
An isolated polynucleotide molecule comprising at least 10 nucleotides of the polynucleotide sequence as shown in SEQ ID NO:1.
Dependencies are inferred from the claim text.