Peptides from the E2, E6, and E7 proteins of human papilloma viruses 16 and 18 for detecting and/or diagnosing cervical and other human papillomavirus associated cancers

An isolated protein sequence or peptide from HPV for detecting or diagnosing cancer or cellular abnormalities, said isolated protein sequence or peptide selected from the group consisting of:

• an E2 early coding region of HPV 18 as set forth in SEQ. ID. NO.:
• 1;
• an E2 early coding region of HPV 16 as set forth in SEQ. ID. NO.:
• 2;
• an E2 early coding region of HPV 16 as set forth in SEQ. ID. NO.:
• 3;
• an E6 early coding region of HPV 16 as set forth in SEQ. ID. NO.:
• 4;
• an E6 early coding region of HPV 18 as set forth in SEQ. ID. NO.:
• 5;
• an E7 early coding region of HPV 16 as set forth in SEQ. ID. NO.:
• 6;
• an E7 early coding region of HPV 16 as set forth in SEQ. ID. NO.:
• 7;
• and
• an E7 early coding region of HPV 18 as set forth in SEQ. ID. NO.:
• 8.

A method for detecting or diagnosing cancer or cellular abnormalities, said method comprising the steps of:

• reacting a sample of body fluid or tissue likely to contain antibodies with one or more protein sequences or peptides isolated from the E2, E6 and E7 early coding regions of human papillomavirus (HPV) selected from the group consisting of an E2 early coding region of HPV 18 as set forth in SEQ. ID. NO.:
• 1, an E2 early coding region of HPV 16 as set forth in SEQ. ID. NO.:
• 2, an E2 early coding region of HPV 16 as set forth in SEQ. ID. NO.:
• 3, an E6 early coding region of HPV 16 as set forth in SEQ. ID. NO.:
• 4, an E6 early coding region of HPV 18 as set forth in SEQ. ID. NO.:
• 5, an E7 early coding region of HPV 16 as set forth in SEQ. ID. NO.:
• 6, an E7 early coding region of HPV 16 as set forth in SEQ. ID. NO.:
• 7 and an E7 early coding region of HPV 18 as set forth in SEQ. ID. NO.:
• 8;
• forming an antibody-peptide complex comprising at lease one of said isolated protein sequences or peptides and said sample antibodies;
• and
• detecting said antibody-peptide complex.