Novel derivatives of dicarboxylic acid having pharmaceutical properties
AssigneeBayer Aktiengesellschaft
InventorsMichael Harter, Michael Hahn, Claudia Hirth-Dietrich, Andreas Knorr, Elke Stahl, Johannes-Peter Stasch, Frank Wunder
Life of this patent
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Abstract
The invention relates to compounds of formula (I), to a method for their production and to their use as medicaments.
Claims14
A compound of the general formula (I)
- 48
- in which
- R1 is located in the meta- or para-position to the radical W and represents a radical from the group consisting of H, halogen and OCF3;
- R2 represents H, or halogen;
- R3 represents H or halogen;
- R4 represents C1-6-alkyl, C3-8-cycloalkyl, CF3, OCF3, F, Cl, OMe or phenyl, where the phenyl radical may additionally carry a substituent from the group consisting of halogen, CN, C1-6-alkoxy, CF3, C1-6-alkyl;
- V is located in the ortho- or meta-position to the radical w and represents O, CH2O, OCF2 or O-C1-6-alkyl-O;
- W represents CH2 or CH2CH2;
- and salts, isomers and hydrates thereof.
A compound as claimed in claim. 1, characterized in that
- R1 is located in the meta-position to the radical W and represents a radical from the group consisting of H, F, Cl and Br;
- R2 represents H;
- R3 represents H;
- R4 represents methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, t-butyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, or phenyl, where the phenyl radical may additionally carry a substituent from the group consisting of F, Cl, Br, CN, OMe, CF3, methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, t-butyl;
- V is located in the ortho-position to the radical W and represents CH2O;
- W represents CH2CH2;
- and salts, isomers and hydrates thereof.
A medicament, comprising at least one compound of the general formula (I) as claimed in any of the preceding claims.
The use of compounds of the formula (I) as claimed in any of the preceding claims for preparing a medicament for treating cardiovascular disorders.
The use of compounds of the general formula (I) as claimed in any of the preceding claims for preparing medicaments for treating angina pectoris, ischemias and heart failure.
The use of compounds of the general formula (I) as claimed in any of the preceding claims for preparing medicaments for treating hypertension, thromboembolic disorders, arteriosclerosis and venous diseases.
The use of compounds of the general formula (I) as claimed in any of the preceding claims for preparing medicaments for treating fibrotic disorders.
Dependencies are inferred from the claim text.