Compounds and methods for inhibition of phospholipase A2 and cyclooxygenase-2
OwnerBrian Kellerinventor
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Abstract
The present invention comprises a group of related lipid molecules, and methods for their use, that maybe used to treat inflammation and certain inflammation related diseases. The group of related lipid molecules are capable of inhibiting certain enzyme systems including phospholipase A2, and cyclooxygenase-2. The group of related lipid molecules of the invention may be characterized by specific structural characteristics, or by specific biological activity, including inhibition of the previously listed enzymes.
Claims60
1) A lipid compound represented by the formula
- 5
- wherein R1 is a long chain fatty acid, R2 is a long chain fatty chain between 11 and 25 carbons in length, and wherein the variable “n” is an integer between 11 and 46, and
- wherein said compound is characterized by the ability to inhibit biological activity of phospholipase A2.
22) A composition of matter comprising one or more lipids having the formula
- 6
- wherein R1 is a long chain fatty acid chain between 11 and 25 carbons in length, R2 is a long chain fatty chain between 11 and 25 carbons in length, and wherein the variable “n” is an integer between 11 and 46, and
- wherein said compound is further characterized by the ability to inhibit biological activity of phospholipase A2.
46) A method for treating an inflammation related condition in a mammal comprising the step of administering an effective amount of a composition of matter comprising one or more lipids having the formula
- 7
- Wherein R1 is a long chain fatty acid between 11 and 25 carbons in length, R2 is a long chain fatty between 11 and 25 carbons in length, and wherein the variable “n” is an integer between 11 and 46.
Dependencies are inferred from the claim text.