Compounds of the general formula I
- 10
- which referring to R1 are present as racemates as well as L- or D-configured cbmpounds, respectively, and as EIZ-mixtures as well as E- or Z-isomers, respectively, and wherein
- R1 represents
- (a) OH or (C1-C8)-alkoxy optionally substituted with aryl or (C3-C8)-cycloalkyloxy;
- or
- (b) a group of formula —N(R4R5), wherein R4 and R5 independently of each other represent hydrogen, (C1-C8)-alkyl, (C1-C8)-alkyl optionally substituted with 1 to 3-times identically or differently substituted aryl, (C3-C8)— cycloalkyl, (C3-C8)-cycloalkyl-(C1-C4)-alkyl, N H2, NHR6 or NR6R7, wherein R6 and R7 independently of each other represent (C1-C8)-alkyl, (C3-C8)-cycloalkyl, optionally 1 to 3-times identically or differently substituted aryl, optionally 1 to 3-times identically or differently substituted heteroaryl, or R6 and R7 together with the nitrogen atom to which they are bound represent a thiazoline, thiazolidine, oxazoline, oxazolidine or morpholine ring, which can be substituted 1 to 3-times identically or differently;
- or
- (c) a group of formula
- 11
- wherein m represents integer 1 or 2 and wherein one of the methylene groups can be substituted with a hydroxyl, carboxyl or (C1-C8)-alkyl residue or a (C1-C8)-alkyl residue substituted with an optionally 1 to 3-times identically or differently substituted aryl, and R8 has one of the above denotations of R1 mentioned under (a) and (b), wherein a further aromatic or cycloaliphatic ring can be condensed in position 2, 3 or 3,4 related to the nitrogen atom;
- or
- (d) a group of formula
- 12
- wherein p and r independently of each other can be 1 or 2 and wherein one of the methylene groups can be substituted with a hydroxyl, carboxyl, (C1-C8)-alkyl or a (C1-C8)-alkyl residue substituted with an optionally 1 to 3-times identically or differently substituted aryl, and R8 has one of the above denotations of R1 mentioned under (a) and (b), wherein a further aromatic or cycloaliphatic ring can be condensed in position 2, 3 or 3,4 related to the nitrogen atom;
- or
- (e) a piperidyl group which is optionally substituted with a (C1-C8)-alkylcarbonyl, a (C1-C8)-alkoxycarbonyl, a (C1-C4)-alkyl or a hydroxyl residue in one of the positions 2, 3 and 4, wherein a further aromatic or cycloaliphatic ring can be condensed in position 2, 3 or 3,4 related to the nitrogen atom;
- or
- (f) a group of formula
- 13
- wherein R9 represents H, (C1-C8)-alkyl, (C2-C8)-alkenyl, (C2-C8)-alkinyl, formyl, (C1-C8)-alkylcarbonyl, (C2-C8)-alkenylcarbonyl, (C2-C8)-alkinyl-carbonyl, cyano, (C1-C8)-alkoxycarbonyl, (C2-C8)-alkenyloxycarbonyl, (C2-C8)-alkinyloxycarbonyl, (C3-C8)-cycloalkyl, (C3-C8)-cycloalkylcarbonyl, (C3-C8)-cycloalkyloxycarbonyl;
- (C3-C8)-heterocyclyl, (C3-C8)-heterocyclyl-carbonyl, (C3-C8)-heterocyclyloxycarbonyl with 1 to 3 heteroatoms each;
- aryl, arylcarbonyl, aryloxycarbonyl;
- heteroaryl, heteroarylcarbonyl, heteroaryloxycarbonyl with 1 to 3 heteroatoms each;
- a carboxamide residue of formula —CON(R4R5) or a thiocarboxamide residue of formula —CSN(R4R5), wherein R4 and R5 independently of each other represent hydrogen, (C1-C8)-alkyl, (C2-C8)-alkenyl, (C2-C8)-alkinyl, (C3-C8)-cycloalkyl, aryl or heteroaryl, or R4 and R5 together with the nitrogen atom to which they are bound form a 5- to 7-member ring which can comprise 1 to 2 further heteroatoms (N, O, S) and which can be optionally 1 to 3-times identically or differently substituted, or a —SO2Y residue, wherein Y represents (C1-C8)-alkyl, (C2-C8)-alkenyl, (C2-C8)-alkinyl, (C3-C8)-cyclo-alkyl, aryl, heteroaryl, aryloxy or N(R4R5);
- wherein all the alkyl, alkenyl and alkinyl residues of the alkyl-, alkenyl- and alkinyl-, respectively, containing groups can be substituted 1 to 3-times identically or differently and all the cycloalkyl, heterocyclyl, aryl and heteroaryl residues of the cycloalkyl-, heterocyclyl-, aryl- and heteroaryl-, respectively, containing groups can be substituted 1 to 3-times identically or differently;
- R2 represents an aryl or heteroaryl residue optionally substituted 1 to 3-times identically or differently or a camphor residue;
- and
- R3 represents hydrogen, amino or hydroxy;
- wherein these compounds can be present as free bases as well as salts with inorganic acids or as salts with organic acids.