Tetrahydrocannabinol compositions and methods of manufacture and use thereof

A method for manufacture of an injectable pharmaceutical composition comprising tetrahydrocannabinol, ethanol, water, and a pharmaceutically acceptable amphiphilic excipient, said method comprising the steps of:

• admixing tetrahydrocannabinol with ethanol to form a first mixture;
• admixing water with a pharmaceutically acceptable amphiphilic excipient to form a second mixture;
• and admixing the first mixture with the second mixture to form a third mixture, wherein said third mixture comprises an intermediate or a finished product in the manufacture of the injectable pharmaceutical composition.