Receptor Antagonists

A condensed-ring-pyrimidine derivative represented by general formula (II):

• 1495
• <wherein k represents an integer of 1 to 3;
• R1A represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, a substituted or unsubstituted heterocyclic group, or substituted or unsubstituted heterocycle-lower alkyl;
• R2A represents —N(—R3A) (—R4A) (wherein R3A and R4A are the same or different, and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, a substituted or unsubstituted heterocyclic group, or substituted or unsubstituted heterocycle-lower alkyl, or R3A and R4A form a substituted or unsubstituted heterocyclic group together with the adjacent nitrogen atom) or general formula (C):
• 1496
• {wherein -A1A-A2A- represents —Y1A—C(═O)—Y2A—CH2—CH2— [wherein Y1A and Y2A are the same or different, and each represents an oxygen atom or —N(—R5A)— (wherein R5A represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, a substituted or unsubstituted heterocyclic group, or substituted or unsubstituted heterocycle-lower alkyl)] or —Y3A—CH2—Y4A—C(═O)— (wherein Y3A and Y4A have the same meanings as the above-described Y1A and Y2A, respectively)};
• and
• -QA- represents (d) —N═C(—R7A)— [wherein R7A represents —O(—R8A) (wherein R8A represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkanoyl, substituted or unsubstituted aroyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, a substituted or unsubstituted heterocyclic group, or substituted or unsubstituted heterocycle-lower alkyl), —N(—R9A) (—R10A) (wherein R9A and R10A are the same or different, and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted lower alkenyl, substituted or unsubstituted lower alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted lower alkanoyl, substituted or unsubstituted aroyl, substituted or unsubstituted aralkyl, a substituted or unsubstituted heterocyclic group, or substituted or unsubstituted heterocycle-lower alkyl, or R9A and R10A form a substituted or unsubstituted heterocyclic group together with the adjacent nitrogen atom) or —S(—R11A) (wherein R11A represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aralkyl, or substituted or unsubstituted heterocycle-lower alkyl)],
• (e) —N(—R12A)—C(═O) (wherein R12A represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aralkyl, or substituted or unsubstituted heterocycle-lower alkyl) or
• (f) general formula (D):
• 1497
• (wherein m represents an integer of 1 to 3;
• and R13A and R14A are the same or different, and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, a substituted or unsubstituted heterocyclic group, or substituted or unsubstituted heterocycle-lower alkyl), provided that when R1A is furyl and -QA- is —N═C(—R7A) in which R7A is amino or 3,4-dimethoxybenzylamino, R2A is not morpholino, 1-piperazinyl, substituted 1-piperazinyl in which the 4-position is substituted by lower alkyl or aryl, phenylamino or substituted phenylamino in which the 4-position is substituted by halogen> or a pharmaceutically acceptable salt thereof.