Thiazole derivatives

A compound of formula (I)

• 21
• wherein
• X is N and Y is S;
• or
• X is S and Y is N;
• R1 is aryl or heteroaryl;
• R2 is hydrogen, lower-alkyl or fluoro-lower-alkyl;
• R3, R4, R5 and R6 independently from each other are selected from hydrogen, hydroxy, lower-alkenyl, halogen, lower-alkyl, fluoro-lower-alkyl, hydroxy-lower-alkyl, lower-alkoxy-lower-alkyl, lower-alkoxy, fluoro-lower-alkoxy, hydroxy-lower-alkoxy, and lower-alkoxy-lower-alkoxy, wherein at least one of R3, R4, R5 and R6 is not hydrogen, or
• R3 and R4 are bonded to each other to form a ring together with the carbon atoms to which they are attached, and R3 and R4 together are —CH═CH—S—, —S—CH═CH—, —CH═CH—O—, —O—CH═CH—, —CH═CH—CH═CH—, —(CH2)3-5—, —O—(CH2)2-3— or —(CH2)2-3—O—, and R5 and R6 are as defined above;
• R7 is lower-alkyl, lower-alkoxy, lower-alkenyloxy, aryloxy or aryl-lower-alkoxy;
• R8 is hydrogen or lower-alkyl;
• R9 and R10 independently from each other are hydrogen, lower-alkyl, lower-alkenyl, cycloalkyl, phenyl or [1,3]dioxan-2-ethyl;
• n is 1, 2 or 3;
• or a pharmaceutically acceptable salt or a pharmaceutically acceptable ester thereof.