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US 2004/0110802 A1Published application
Antibacterial benzoic acid derivatives
OwnerAtli Thorarensen, J. Craig Ruble +4inventors
InventorsAtli Thorarensen, J. Craig Ruble, Jed F. Fisher, Donna Lee Romero, Thomas J. Beauchamp, Jill M. Northuis
Life of this patent
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Abstract
The invention provides antimicrobial agents and methods of using the agents for sterilization, sanitation, antisepsis, disinfection, and treatment of infections in mammals.
Claims46
A compound of formula I,
- 1610
- or a pharmaceutically acceptable salt thereof,
- wherein
- X═NH
- Y═CO, CS, —C(═N—CN) or
- X and Y together form an alkene, or C3-C5 cycloalkyl;
- R1 is —COOH;
- R2 is an electron withdrawing group;
- and
- R4 is an optionally substituted HET, provided that the HET is not simultaneously substituted with a sulfonamide and a urea or thiourea.
7 more elements
The compound of 26, wherein at least one of the R8 substituents is benzyl or —CH2-substituted phenyl.
A compound selected from
- 5-cyano-2-[(1H-indol-2-ylcarbonyl)amino]benzoic acid;
- 5-cyano-2-{[(5-methoxy-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 2-({[5-(benzyloxy)-1H-indol-2-yl]carbonyl}amino)-5-cyanobenzoic acid;
- 5-cyano-2-{[(1-methyl-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 2-({[6-(benzyloxy)-1H-indol-2-yl]carbonyl}amino)-5-cyanobenzoic acid;
- 2-{[(7-chloro-1H-indol-2-yl)carbonyl]amino}-5-cyanobenzoic acid;
- 5-cyano-2-{[(4-methoxy-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 5-bromo-2-{[(1-methyl-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 2-{[(6-chloro-1H-indol-2-yl)carbonyl]amino}-5-cyanobenzoic acid;
- 2-{[(1-benzyl-1H-indol-2-yl)carbonyl]amino}-5-cyanobenzoic acid;
- 5-cyano-2-{[(1-ethyl-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 5-cyano-2-({[7-(phenylsulfonyl)-1H-indol-2-yl]carbonyl}amino)benzoic acid;
- 2-{[(1-allyl-1H-indol-2-yl)carbonyl]amino}-5-cyanobenzoic acid;
- 5-cyano-2-({[1-(cyclohexylmethyl)-1H-indol-2-yl]carbonyl}amino)benzoic acid
- {[1-(2-methoxyethyl)-1H-indol-2-yl]carbonyl}amino)benzoic acid;
- 5-cyano-2-{[(1-pentyl-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 2-{[(1-butyl-1H-indol-2-yl)carbonyl]amino}-5-cyanobenzoic acid;
- 5-cyano-2-{[(1-propyl-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 5-chloro-2-{[(1-propyl-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 2-{[(1-butyl-1H-indol-2-yl)carbonyl]amino}-5-chlorobenzoic acid;
- 5-chloro-2-{[(1-pentyl-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 5-chloro-2-({[1-(2-methoxyethyl)-1H-indol-2-yl]carbonyl}amino)benzoic acid;
- 5-chloro-2-({[1-(cyclohexylmethyl)-1H-indol-2-yl]carbonyl}anino)benzoic acid;
- 2-{[(1-allyl-1H-indol-2-yl)carbonyl]amino}-5-chlorobenzoic acid;
- 2-{[(1-allyl-1H-indol-2-yl)carbonyl]amino}-5-bromobenzoic acid;
- 5-bromo-2-({[1-(cyclohexylmethyl)-1H-indol-2-yl]carbonyl}amino)benzoic acid;
- 5-bromo-2-({[1-(2-methoxyethyl)-1H-indol-2-yl]carbonyl}amino)benzoic acid;
- 5-bromo-2-{[(1-pentyl-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 5-bromo-2-{[(1-butyl-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 5-bromo-2-{[(1-propyl-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 2-{[(1-benzyl-1H-indol-2-yl)carbonyl]amino}-5-chlorobenzoic acid;
- 2-{[(1-benzyl-1H-indol-2-yl)carbonyl]amino}-5-bromobenzoic acid;
- 5-bromo-2-{[(1-isopropyl-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 5-cyano-2-{[(1-isopropyl-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 5-chloro-2-{[(1-methyl-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 5-chloro-2-{[(1-isobutyl-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 5-bromo-2-{[(1-isobutyl-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 5-cyano-2-{[(1-isobutyl-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 5-cyano-2-({[1-(3-phenylpropyl)-1H-indol-2-yl]carbonyl}amino)benzoic acid;
- 5-chloro-2-({[1-(3-phenylpropyl)-1H-indol-2-yl]carbonyl}amino)benzoic acid;
- 5-bromo-2-({[1-(3-phenylpropyl)-1H-indol-2-yl]carbonyl}amino)benzoic acid;
- 5-chloro-2-({[7-(phenylsulfonyl)-1H-indol-2-yl]carbonyl}amino)benzoic acid;
- 5-bromo-2-({[7-(phenylsulfonyl)-1H-indol-2-yl]carbonyl}amino)benzoic acid;
- 5-cyano-2-({[1-methyl-7-(phenylsulfonyl)-1H-indol-2-yl]carbonyl}amino)benzoic acid;
- 5-bromo-2-({[1-methyl-7-(phenylsulfonyl)-1H-indol-2-yl]carbonyl}amino)benzoic acid;
- 5-chloro-2-({[1-methyl-7-(phenylsulfonyl)-1H-indol-2-yl]carbonyl}amino)benzoic acid;
- 5-cyano-2-[({7-[(phenylacetyl)amino]-1H-indol-2-yl}carbonyl)amino]benzoic acid;
- 2-({[7-(benzoylamino)-1H-indol-2-yl]carbonyl}amino)-5-cyanobenzoic acid;
- 2-{[(7-{[(acetyloxy)acetyl]amino}-1H-indol-2-yl)carbonyl]amino}-5-cyanobenzoic acid;
- 5-cyano-2-[({7-[(cyclopentylcarbonyl)amino]-1H-indol-2-yl}carbonyl)amino]benzoic acid;
- 2-{[(7-amino-1H-indol-2-yl)carbonyl]amino}-5-cyanobenzoic acid;
- 2-{[(7-{[(6-chloropyridin-3-yl)carbonyl]amino}-1H-indol-2-yl)carbonyl]amino}-5-cyanobenzoic acid;
- 5-cyano-2-[({7-[(isoxazol-5-ylcarbonyl)amino]-1H-indol-2-yl}carbonyl)amriino]benzoic acid;
- 5-cyano-2-[({7-[(2,4-difluorobenzoyl)amino]-1H-indol-2-yl}carbonyl)amino]benzoic acid;
- 5-cyano-2-[({7-[(fluoroacetyl)amino]-1H-indol-2-yl}carbonyl)amimo]benzoic acid;
- 2-({[7-(acetylamino)-1H-indol-2-yl]carbonyl}amino)-5-cyanobenzoic acid;
- 2-{[(7-{[(4-chlorophenyl)acetyl]amino}-1H-indol-2-yl)carbonyl]amino}-5-cyanobenzoic acid;
- 5-cyano-2-{[(7-{[(4-methoxyphenyl)acetyl]amino}-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 5-cyano-2-[({7-[(cyclopentylacetyl)amino]-1H-indol-2-yl}carbonyl)amino]benzoic acid;
- 5-cyano-2-[({7-[(3-fluorobenzoyl)amimo]-1H-indol-2-yl}carbonyl)amino]benzoic acid;
- 5-cyano-2-[({7-[(cyclohexylcarbonyl)amino]-1H-indol-2-yl}carbonyl)amimo]benzoic acid;
- 5-cyano-2-({[7-(propionylamino)-1H-indol-2-yl]carbonyl}amino)benzoic acid;
- 5-cyano-2-[({7-[(5-methoxy-5-oxopentanoyl)amino]-1H-indol-2-yl}carbonyl)amino]benzoic acid;
- 2-({[7-(butyrylamino)-1H-indol-2-yl]carbonyl}anino)-5-cyanobenzoic acid;
- 2-[({7-[(4-bromobenzoyl)amino]-1H-indol-2-yl}carbonyl)amimo]-5-cyanobenzoic acid;
- 5-cyano-2-[({7-[(3-phenylpropanoyl)amino]-1H-indol-2-yl}carbonyl)amino]benzoic acid;
- 5-cyano-2-[({7-[(phenoxyacetyl)amino]-1H-indol-2-yl}carbonyl)amimo]benzoic acid;
- 5-cyano-2-[({7-[(3-cyclopentylpropanoyl)amino]-1H-indol-2-yl}carbonyl)amino]benzoic acid;
- 5-cyano-2-[({7-[(3-methoxy-3-oxopropanoyl)amino]-1H-indol-2-yl}carbonyl)amino]benzoic acid;
- 5-cyano-2-[({7-[(2-ethylhexanoyl)amino]-1H-indol-2-yl}carbonyl)amino]benzoic acid;
- 5-cyano-2-{[(7-{[(3,4-dimethoxyphenyl)acetyl]amino}-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 5-cyano-2-[({7-[(3,5,5-trimethylhexanoyl)amino]-1H-indol-2-yl}carbonyl)amino]benzoic acid;
- 5-cyano-2-[({7-[(cyclopropylcarbonyl)amino]-1H-indol-2-yl}carbonyl)amino]benzoic acid;
- 5-cyano-2-[({7-[(methoxyacetyl)amino]-1H-indol-2-yl}carbonyl)amimo]benzoic acid;
- 5-cyano-2-[({7-[(3-methylbutanoyl)amino]-1H-indol-2-yl}carbonyl)amino]benzoic acid;
- 5-cyano-2-({[7-(pentanoylamino)-1H-indol-2-yl]carbonyl}amino)benzoic acid;
- 5-cyano-2-{[(7-{[(4,7,7-trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptyl)carbonyl}amino-1H-indol-2-yl)carbonyl]amino]benzoic acid;
- 2-{[(7-{[chloro(phenyl)acetyl]amino}-1H-indol-2-yl)carbonyl]amino}-5-cyanobenzoic acid;
- 2-{[(7-{[(benzyloxy)acetyl]amino}-1H-indol-2-yl)carbonyl]amino}-5-cyanobenzoic acid;
- 5-cyano-2-[({7-[(3-ethoxy-3-oxopropanoyl)amino]-1H-indol-2-yl}carbonyl)amino]benzoic acid;
- 2-[({7-[(1-adamantylcarbonyl)amino]-1H-indol-2-yl}carbonyl)amimo]-5-cyanobenzoic acid;
- 5-cyano-2-({[7-(hexanoylamino)-1H-indol-2-yl]carbonyl}amino)benzoic acid;
- 5-cyano-2-[({7-[(2-phenylbutanoyl)amino]-1H-indol-2-yl}carbonyl)amino]benzoic acid;
- 5-cyano-2-({[7-(heptanoylamino)-1H-indol-2-yl]carbonyl}amino)benzoic acid;
- 2-{[(7-{[(acetyloxy)(phenyl)acetyl]amino}-1H-indol-2-yl)carbonyl]amino}-5-cyanobenzoic acid;
- 5-cyano-2-{[(7-{[(2-phenylcyclopropyl)carbonyl]amino}-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 5-cyano-2-[({7-[(thien-2-ylcarbonyl)amino]-1H-indol-2-yl}carbonyl)amino]benzoic acid;
- 5-cyano-2-[({7-[(2-methylbutanoyl)amino]-1H-indol-2-yl}carbonyl)amino]benzoic acid;
- 5-cyano-2-[({7-[(8-methoxy-8-oxooctanoyl)amino]-1H-indol-2-yl}carbonyl)amino]benzoic acid;
- 5-cyano-2-[({7-[(2-ethylbutanoyl)amino]-1H-indol-2-yl}carbonyl)amino]benzoic acid;
- 5-cyano-2-({[7-(octanoylamino)-1H-indol-2-yl]carbonyl}amino)benzoic acid;
- 5-cyano-2-[({7-[(cyclobutylcarbonyl)amino]-1H-indol-2-yl}carbonyl)amino]benzoic acid;
- 5-cyano-2-({[7-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1H-indol-2-yl]carbonyl}amino)benzoic acid;
- 2-({[7-({[2-(benzylthio)-1,3-thiazol-4-yl]carbonyl}amino)-1H-indol-2-yl]carbonyl}amino)-5-cyanobenzoic acid;
- 5-cyano-2-{[(7-{[3-(morpholin-4-ylsulfonyl)benzoyl]amino}-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 5-cyano-2-[({7-[(1H-indol-2-ylcarbonyl)amino]-1H-indol-2-yl}carbonyl)amino]benzoic acid;
- 5-cyano-2-{[(7-{[(1-methyl-1H-indol-2-yl)carbonyl]amino}-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 5-cyano-2-{[(7-{[(5-phenylisoxazol-3-yl)carbonyl]amino}-1H-indol-2-yl)carbonyl]amino}benzoic
- 5-cyano-2-[({7-[(5-phenylpentanoyl)amino]-1H-indol-2-yl}carbonyl)amino]benzoic acid;
- 5-cyano-2-[({7-[(4-phenylbutanoyl)amino]-1H-indol-2-yl}carbonyl)amino]benzoic acid;
- 5-cyano-2-{[(7-{[4-(4-methoxyphenyl)butanoyl]amino}-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 2-{[(7-{[(2-chlorophenyl)acetyl]amino}-1H-indol-2-yl)carbonyl]amino}-5-cyanobenzoic acid;
- 5-cyano-2-{[(7-{[(2;4-dichlorophenyl)acetyl]amino}-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 5-cyano-2-{[(7-{[(3,4-dichlorophenyl)acetyl]amino}-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 2-{[(7-{[(3-chlorophenyl)acetyl]amino}-1H-indol-2-yl)carbonyl]amino}-5-cyanobenzoic acid;
- 5-cyano-2-({[7-({[3-(trifluoromethyl)phenyl]acetyl}anino)-1H-indol-2-yl]carbonyl}amino)benzoic acid;
- 5-cyano-2-{[(7-{[(3-methylphenyl)acetyl]amino}-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 2-{[(7-{[(4-tert-butylphenyl)acetyl]amino}-1H-indol-2-yl)carbonyl]amino}-5-cyanobenzoic acid;
- 5-cyano-2-{[(7-{[(3-methoxyphenyl)acetyl]amino}-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 5-cyano-2-{[(7-{[(2-methoxyphenyl)acetyl]amino}-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 5-cyano-2-{[(7-{[(2-methylphenyl)acetyl]amino}-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 5-cyano-2-({[7-({[4-(trifluoromethyl)phenyl]acetyl}amino)-1H-indol-2-yl]carbonyl}amino)benzoic acid;
- 5-cyano-2-{[(7-{[(4-isopropylphenyl)acetyl]amino}-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 5-cyano-2-{[(7-{[(4-methylphenyl)acetyl]amino}-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 5-cyano-2-{[(7-{[(4-fluorophenyl)acetyl]amino}-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 5-cyano-2-({[7-({[2-(trifluoromethyl)phenyl]acetyl}anino)-1H-indol-2-yl]carbonyl}amino)benzoic acid;
- 5-cyano-2-{[(7-{[(3-fluorophenyl)acetyl]aminol}-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 5-cyano-2-{[(7-{[(phenylthio)acetyl]amino}-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 5-cyano-2-[({7-[(2-naphthylacetyl)amino]-1H-indol-2-yl}carbonyl)amino]benzoic acid;
- 5-cyano-2-[({7-[(1-naphthylacetyl)amino]-1H-indol-2-yl}carbonyl)amino]benzoic acid;
- 5-cyano-2-{[(7-{[(2-naphthyloxy)acetyl]amino}-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 5-cyano-2-[({7-[(2-propoxybenzoyl)amino]-1H-indol-2-yl}carbonyl)amino]benzoic acid;
- 5-cyano-2-[({7-[(tetrahydrofiran-3-ylcarbonyl)amino]-1H-indol-2-yl}carbonyl)amino]benzoic acid;
- 5-cyano-2-{[(7-{[(1-methylcyclopropyl)carbonyl]amino}-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 5-cyano-2-{[(7-{[(4-ethoxyphenyl)acetyl]amino}-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 2-[({7-[(1-benzothien-3-ylacetyl)amino]-1H-indol-2-yl}carbonyl)amino]-5-cyanobenzoic acid;
- 2-[({7-[(1,1 ′-biphenyl-4-ylcarbonyl)amimo]-1H-indol-2-yl}carbonyl)amino]-5-cyanobenzoic acid;
- 2-[({7-[(4-butoxybenzoyl)amino]-1H-indol-2-yl}carbonyl)arniino]-5-cyanobenzoic acid;
- 5-cyano-2-{[(7-{[2-(2-phenylethyl)benzoyl]amino}-1H-indol-2-yl)carbonyl]amimo}benzoic acid;
- 2-[({7-[(1,1 ′-biphenyl-2-ylcarbonyl)amino]-1H-indol-2-yl}carbonyl)amino]-5-cyanobenzoic acid;
- 5-cyano-2-{[(7-{[4-(ethylthio)benzoyl]aminol}-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 5-cyano-2-{[(7-{[2-(methylsulfonyl)benzoyl]amino)}-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 5-cyano-2-{[(7-{[(2,6-dichlorophenyl)acetyl]amino}-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 2-[({7-[(1,1 ′-biphenyl-4-ylacetyl)amino]-1H-indol-2-yl}carbonyl)amimo]-5-cyanobenzoic acid;
- 2-[({7-[(1,3-benzodioxol-5-ylacetyl)amino]-1H-indol-2-yl}carbonyl)amino]-5-cyanobenzoic acid;
- 5-cyano-2-[({7-[(3,5-dimethylbutanoyl)amino]-1H-indol-2-yl}carbonyl)amino]benzoic acid;
- 5-cyano-2-[({7-[(thien-2-ylacetyl)amino]-1H-indol-2-yl}carbonyl)amino]benzoic acid;
- 5-cyano-2-{[(7-{[(3-methyl-5-phenylisoxazol-4-yl)carbonyl]amimo}-1H-indol-2-yl) carbonyl]amino}benzoicacid;
- 5-cyano-2-({[7-({[2-(2-methoxyethoxy)ethoxy]acetyl}amino)-1H-indol-2-yl]carbonyl}amino)benzoic acid;
- 5-cyano-2-[({7-[(2-hydroxybenzoyl)amino]-1H-indol-2-yl}carbonyl)amino]benzoic acid;
- 5-cyano-2-({[7-({[4-(trifluoromethoxy)phenyl]sulfonyl}amino)-1H-indol-2-yl]carbonyl}amino)benzoic acid;
- 5-cyano-2-({[7-(prolylamino)-1H-indol-2-yl]carbonyl}amino)benzoic acid;
- 5-cyano-2-{[(7-{[(3-methylisoxazol-5-yl)acetyl]amino}-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 2-[({7-[(benzylsulfonyl)amino]-1H-indol-2-yl}carbonyl)amino]-5-cyanobenzoic acid;
- 5-cyano-2-{[(1-methyl-7-{[3-(morpholin-4-ylsulfonyl)benzoyl]amino}-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 5-cyano-2-{[(7-{[(4-fluorophenyl)acetyl]amino}-1-methyl-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 5-cyano-2-[({7-[(fluoroacetyl)amino]-1-methyl-1H-indol-2-yl}carbonyl)amino]benzoic acid;
- 5-cyano-2-{[(1-methyl-7-{[(1-methyl-1H-indol-2-yl)carbonyl]amino}-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 2-({[6-(benzyloxy)-1-methyl-1H-indol-2-yl]carbonyl}amino)-5-cyanobenzoic acid;
- 5-cyano-2-{[(6-methoxy-1-methyl-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 5-cyano-2-[({1-methyl-7-[(morpholin-4-ylcarbonyl)amino]-1H-indol-2-yl}carbonyl)amino]benzoic acid;
- 5-cyano-2-({[1-methyl-7-({[(tetrahydrofuran-2-ylmethyl)amimo]carbonyl}amino)-1H-indol-2-yl]carbonly}amino)benzoic acid;
- 5-cyano-2-{[(7-hydroxy-1-methyl-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 2-{[(7-{[(benzylamino)carbonyl]amimo}-1-methyl-1H-indol-2-yl)carbonyl]amino}-5-cyanobenzoic acid;
- 5-cyano-2-({[7-({[(2,3-dihydroxypropyl)amino]carbonyl}amino)-1-methyl-1H-indol-2-yl]carbonyl}amino)benzoic acid;
- 1-[{[(2-{[(2-carboxy-4-cyanophenyl)amino]carbonyl}-1-methyl-1H-indol-7-yl)amino]carbonyl}(methyl)amino]benzoic (methyl)amino]-1-deoxyhexitol;
- 5-cyano-2-({[7-(2,3-dihydro-1,4-benzodioxin-2-ylmethoxy)-1-methyl-1H-indol-2-yl]carbonyl}amino)benzoic acid;
- 2-({[7-(benzyloxy)-1H-indol-2-yl]carbonyl}amino)-5-cyanobenzoic acid;
- 5-cyano-2-({([1-methyl-7-(3-phenoxypropoxy)-1H-indol-2-yl]carbonyl}amino)benzoic acid;
- 5-cyano-2-({[7-(cyclobutylmethoxy)-1-methyl-1H-indol-2-yl]carbonyl}amino)benzoic acid;
- 5-cyano-2-({[7-(2-furylmethoxy)-1-methyl-1H-indol-2-yl]carbonyl}amino)benzoic acid;
- 5-cyano-2-{[(7-{[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy}-1-methyl-1H-indol-2-y6l)carbonyl]amino}benzoic acid;
- 5-cyano-2-{[(7-{[(2R)-2,3-dihydroxypropyl]oxy}—1-methyl-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 5-cyano-2-({[7-(cyclobutyloxy)-1-methyl-1H-indol-2-yl]carbonyl}amino)benzoic acid;
- 5-cyano-2-({[7-(2-methoxy-1-methylethoxy)-1-methyl-1H-indol-2-yl]carbonyl}amino)benzoic acid;
- 5-cyano-2-{[(7-isopropoxy-1-methyl-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 2-({[7-(benzyloxy)-1-methyl-1H-indol-2-yl]carbonyl}amino)-5-cyanobenzoic acid;
- 2-{[(6-sec-butoxy-1-methyl-1H-indol-2-yl)carbonyl]amino}-5-cyanobenzoic acid;
- 2-{[(6-butoxy-1-methyl-1H-indol-2-yl)carbonyl]amino}-5-cyanobenzoic acid;
- 5-cyano-2-({[7-(cyclohexylmethoxy)-1-methyl-1H-indol-2-yl]carbonyl}anino)benzoic acid;
- 5-cyano-2-({[7-(cyclopropylmethoxy)-1-methyl-1H-indol-2-yl]carbonyl}amino)benzoic acid;
- 5-cyano-2-({[1-methyl-7-(tetrahydro-2H-pyran-2-ylmethoxy)-1H-indol-2-yl]carbonyl}amino)benzoic acid;
- 5-cyano-2-({[1-methyl-7-(pentyloxy)-1H-indol-2-yl]carbonyl}amino)benzoic acid;
- 5-cyano-2-({[7-(2-methoxyethoxy)-1-methyl-1H-indol-2-yl]carbonyl}amino)benzoic acid;
- 5-cyano-2-({[7-(2-hydroxy-3-isopropoxypropoxy)-1-methyl-1H-indol-2-yl]carbonyl}amino)benzoic acid;
- 5-cyano-2-[({1-methyl-7-[2-(methylthio)ethoxy]-1H-indol-2-yl}carbonyl)amino]benzoic acid;
- 2-[({7-[(4-azido-3-iodobenzoyl)amino]-1-methyl-1H-indol-2-yl}carbonyl)amino]-5-cyanobenzoic acid;
- 5-cyano-2-[({7-[(3-cyanobenzoyl)amino]-1H-indol-2-yl}carbonyl)amino]benzoic acid;
- 5-cyano-2-[({1-methyl-6-[2-(trifluoromethyl)phenyl]-1H-indol-2-yl}carbonyl)amino]benzoic acid;
- 5-cyano-2-({[1-methyl-6-(2,3,4-trimethoxyphenyl)-1H-indol-2-yl]carbonyl}amino)benzoic acid;
- 5-iodo-2-{[(i -methyl-1H-indol-2-yl)carbonyl]amino}benzoic acid;
- 2-({[4-(benzylsulfanyl)-2-pyridinyl]carbonyl}amino)-5-bromobenzoic acid;
- 2-({[6-(benzylsulfanyl)-2-pyridinyl]carbonyl}anino)-5-bromobenzoic acid;
- 5-bromo-2-({[3-chloro-5-(trifluoromethyl)-2-pyridinyl]carbonyl}amino)benzoic acid;
- 5-bromo-2-[(pyridin-2-ylcarbonyl)amino]benzoic acid;
- 5-bromo-2-{[(5-butylpyridin-2-yl)carbonyl]amino}benzoic acid;
- 5-bromo-2-[(quinolin-2-ylcarbonyl)amino]benzoic acid;
- 5-bromo-2-{[(6-bromopyridin-2-yl)carbonyl]amino}benzoic acid;
- 2-{[(3-benzoylpyridin-2-yl)carbonyl]amino}-5-bromobenzoic acid;
- 2-{[(6-bromopyridin-2-yl)carbonyl]amino}-5-cyanobenzoic acid;
- 5-cyano-2-[(pyridin-2-ylcarbonyl)amino]benzoic acid;
- 5-cyano-2-[(quinolin-2-ylcarbonyl)amino]benzoic acid;
- 5-cyano-2-{[(2-phenylfuro[2,3-c]pyridin-5-yl)carbonyl]amino}benzoic acid;
- 5-cyano-2-{[(3-methylfuro[2,3-c]pyridin-5-yl)carbonyl]amino}benzoic acid;
- 2-({[4-(benzyloxy)pyridin-2-yl]carbonyl}anino)-5-bromobenzoic acid;
- 5-bromo-2-{[(4-chloro-1-oxidopyridin-2-yl)carbonyl]amino}benzoic acid;
- 2-({[4-(benzyloxy)pyridin-2-yl]carbonyl}amino)-5-cyanobenzoic acid;
- 2-({[4-(benzyloxy)-1-oxidopyridin-2-yl]carbonyl}amino)-5-bromobenzoic acid;
- 2-({[4-(benzylthio)-1-oxidopyridin-2-yl]carbonyl}anino)-5-bromobenzoic acid;
- 5-cyano-2-[(isoquinolin-3-ylcarbonyl)amino]benzoic acid;
- 5-bromo-2-[(quinoxalin-2-ylcarbonyl)amino]benzoic acid;
- 5-bromo-2-{[(5-methylpyrazin-2-yl)carbonyl]amino}benzoic acid;
- 5-cyano-2-[(pyrazin-2-ylcarbonyl)amino]benzoic acid;
- 2-({[5-(benzylthio)pyrazin-2-yl]carbonyl}amino)-5-cyanobenzoic acid;
- 2-({[5-(benzylthio)pyrazin-2-yl]carbonyl}anino)-5-bromobenzoic acid;
- 2-({[6-(benzylthio)pyrazin-2-yl]carbonyl}amino)-5-cyanobenzoic acid;
- 2-({[6-(benzylthio)pyrazin-2-yl]carbonyl}amino)-5-bromobenzoic acid;
- 2-({[5-(butylthio)pyrazin-2-yl]carbonyl}amino)-5-cyanobenzoic acid;
- 5-bromo-2-({[5-(sec-butylthio)pyrazin-2-yl]carbonyl}amino)benzoic acid;
- 5-bromo-2-({[5-(butylthio)pyrazin-2-yl]carbonyl}amino)benzoic acid;
- 2-({[5-(butylthio)pyrazin-2-yl]carbonyl}amimo)-5-chlorobenzoic acid;
- 5-bromo-2-({[5-(pentylthio)pyrazin-2-yl]carbonyl}amino)benzoic acid;
- 5-bromo-2-({[5-(hexylthio)pyrazin-2-yl]carbonyl}amino)benzoic acid;
- 2-({[5-(sec-butylthio)pyrazin-2-yl]carbonyl}amino)-5-cyanobenzoic acid;
- 5-cyano-2-({[5-(pentylthio)pyrazin-2-yl]carbonyl}amino)benzoic acid;
- 5-cyano-2-{[(5-{[3-(2-methoxyethoxy)propyl]thio}pyrazin-2-yl)carbonyl]amino}benzoic acid;
- 5-chloro-2-({[5-(pentylthio)pyrazin-2-yl]carbonyl}amino)benzoic acid;
- 5-cyano-2-({[5-(hexylthio)pyrazin-2-yl]carbonyl}amino)benzoic acid;
- 5-chloro-2-({[5-(hexylthio)pyrazin-2-yl]carbonyl}amino)benzoic acid;
- 2-({[5-(sec-butylthio)pyrazin-2-yl]carbonyl}amino)-5-chlorobenzoic acid;
- 5-bromo-2-{[(5-methoxypyrazin-2-yl)carbonyl]amino}benzoic acid;
- 5-cyano-2-({[5-(2-phenylethyl)pyrazin-2-yl]carbonyl}amino)benzoic acid;
- 5-bromo-2-{[(5-{(E)-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]ethenyl}pyrazin-2-yl)carbonyl]amino}benzoic acid;
- 5-cyano-2-({[5-(isopentylthio)pyrazin-2-yl]carbonyl}amino)benzoic acid;
- 5-cyano-2-({[5-(isobutylthio)pyrazin-2-yl]carbonyl}amino)benzoic acid;
- 5-cyano-2-{[(5-methoxypyrazin-2-yl)carbonyl]amino}benzoic acid;
- 5-cyano-2-({[5-(hexyloxy)pyrazin-2-yl]carbonyl}amino)benzoic acid;
- 5-cyano-2-[({5-[2-(trifluoromethyl)phenyl]pyrazin-2-yl}carbonyl)amino]benzoic acid;
- 5-cyano-2-[({5-[(4-methoxybenzyl)thio]pyrazin-2-yl}carbonyl)amino]benzoic acid;
- 5-cyano-2-({[5-(2-fluorophenyl)pyrazin-2-yl]carbonyl}amino)benzoic acid;
- 5-bromo-2-{[(5-{(E)-2-[(2S)-1,4-dioxaspiro[4.5]dec-2-yl]ethenyl}pyrazin-2-yl)carbonyl]amino}benzoic acid;
- 5-cyano-2-({[5-(2-methylphenyl)pyrazin-2-yl]carbonyl}amino)benzoic acid;
- 5-cyano-2-({[5-(2,3,4-trimethoxyphenyl)pyrazin-2-yl]carbonyl}amino)benzoic acid;
- 5-cyano-2-({[5-(nonylthio)pyrazin-2-yl]carbonyl}amino)benzoic acid;
- 5-cyano-2-({[5-(octylthio)pyrazin-2-yl]carbonyl}amino)benzoic acid;
- 5-cyano-2-({[5-(6-methoxypyridin-3-yl)pyrazin-2-yl]carbonyl}anino)benzoic acid;
- 5-cyano-2-{[(5-phenylpyrazin-2-yl)carbonyl]amino}benzoic acid;
- 5-cyano-2-[({5-[4-(methylsulfonyl)phenyl]pyrazin-2-yl}carbonyl)amino]benzoic acid;
- 5-cyano-2-({[5-(3,5-dimethylisoxazol-4-yl)pyrazin-2-yl]carbonyl}amino)benzoic acid;
- 5-cyano-2-({[6-(hexylthio)pyridazin-3-yl]carbonyl}amino)benzoic acid;
- and
- 5-cyano-2-[({6-[2-(trifluoromethyl)phenyl]pyridazin-3-yl}carbonyl)amino]benzoic acid.
239 more elements
Dependencies are inferred from the claim text.