Novel piperidine derivatives as modulators of chemokine receptors

A compound of formula (I):

• 18
• wherein:
• R1 is C3-7 cycloalkyl, C5-7 cycloalkenyl, heterocyclyl (itself optionally substituted by C1-4 alkyl), C1-8 alkyl (optionally substituted by C3-6 cycloalkyl, C5-6 cycloalkenyl, phenyl, heteroaryl, S(O)pR7, CO2R8), C3-6 alkenyl (optionally substituted by phenyl, heteroaryl, S(O)qR9, CO2R10) or C3-8 alkynyl;
• R2 is phenyl, heteroaryl, phenyl(C1-4 alkyl) or heteroaryl(C1-4 alkyl);
• R3, R3a, R4 and R4a are, independently, hydrogen or C1-4 alkyl;
• R5 is hydrogen, C1-4 alkyl (optionally substituted by halogen, hydroxy, C1-4 alkoxy, C3-7 cycloalkyl, SH, C1-4 alkylthio, cyano or S(O)q(C1-4 alkyl)), C3-4 alkenyl, C3-4 alkynyl or C3-7 cycloalkyl;
• R6 is phenyl, heteroaryl, phenylNH, heteroarylNH, phenyl(C1-2)alkyl, heteroaryl(C1-2)alkyl, phenyl(C1-2 alkyl)NH or heteroaryl(C1-2 alkyl)NH;
• R7 and R9 are, independently, C1-4 alkyl, or, when p or q is 0, C1-4 acyl;
• R8 and R10 are, independently, hydrogen or C1-4 alkyl;
• wherein the phenyl and heteroaryl rings of any of the foregoing are independently optionally substituted by halo, cyano, nitro, hydroxy, C1-4 alkyl, C1-4 alkoxy, S(O)mC1-4 alkyl, S(O)2NR11R12, NHS(O)2(C1-4 alkyl), NH2, NH(C1-4 alkyl), N(C1-4 alkyl)2, NHC(O)NH2, C(O)NH2, C(O)NH(C1-4 alkyl), NHC(O)(C1-4 alkyl), CO2H, CO2(C1-4 alkyl), C(O)(C1-4 alkyl), CF3, CHF2, CH2F, CH2CF3 or OCF3;
• R11 and R12 are, independently, hydrogen or C1-4 alkyl, or together with a nitrogen or oxygen atom, may join to form a 5- or 6-membered ring which is optionally substituted with C1-4 alkyl, C(O)H or C(O)(C1-4 alkyl);
• m, p and q are, independently, 0, 1 or 2;
• or a pharmaceutically acceptable salt thereof or a solvate thereof.