Nicotinic acetylcholine receptor ligands

Compounds of the general formula I

• 12
• in which
• A-B is a single or double bond,
• X is O, NR3 or S,
• R1 is hydrogen, A, Ar, arylalkyl, Het, C(O)—R4, SO2—R4, C(S)N(R4)2 or COOR4,
• R2 is A, Ar, arylalkyl, Het, C(O)—R4, SO2—R5, C(S)N(R5)2 or COOR4,
• R3 to R5 are each, independently of one another, hydrogen, A, cycloalkyl, Ar or arylalkyl,
• R6 is hydrogen or A,
• A is a linear or branched alkyl group having from 1 to 10 carbon atoms,
• Ar is phenyl, naphthyl or biphenyl, each of which is unsubstituted or monosubstituted or polysubstituted by Hal, A, OR6, N(R6)2, NO2, CN, COOR6, CON(R6)2, NR6COR6, NR6CON(R6)2, NR6SO2A, COR6, SO2NR6, S(O)mA or Het1,
• arylalkyl is arylalkyl having 7-14 carbon atoms,
• cycloalkyl is cycloalkyl having from 3 to 10 carbon atoms,
• Hal is F, Cl, Br or I,
• Het is a saturated, unsaturated or aromatic monocyclic or bicyclic heterocyclic radical having from 5 to 10 ring members which may contain from 1 to 4 N and/or from 1 to 4 S and/or from 1 to 4 O atoms, and where the heterocyclic radical may be monosubstituted, disubstituted or trisubstituted by Hal, A, —[C(R6)2]o—Ar, —[C(R6)2]o-cycloalkyl, OR6, N(R6)2, NO2, CN, COOR6, CON(R6)2, NR6COA, NR6CON(R6)2, NR6SO2A, COR6, SO2NR6 or S(O)mA and/or carbonyl oxygen,
• Het1 is 3-methyl-2,5-dioxopyrrolidin-1-yl or 1,3-dioxo-1,3-dihydroisoindol-2-yl,
• m is 1 or 2,
• o is 0, 1, 2, 3 or 4,
• and physiologically acceptable salts and solvates thereof.