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OwnerRoger John Griffin, Alan Hilary Calvert +8inventors
InventorsRoger John Griffin, Alan Hilary Calvert, Nicola Jane Curtin, Bernard Thomas Golding, Ian Robert Hardcastle, David Richard Newell, Philip John Jewsbury, Francis Thomas Boyle, Jane Anne Endicott, Martin Edward Mantyla Noble
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The present invention relates to a series of CDK-inhibiting purine derivatives of structural formula (I), or a pharmaceutically acceptable salt and/or prodrug form thereof, wherein: X is O, S or CHRX where RX is H or C1-14 alkyl; D is NZ1Z2 where Z1 is selected from H, C1-4 alkyl, C1-4 hydroxyalkyl, an unsubstituted or substituted aryl or heteroaryl, and an unsubstituted or substituted aralkyl or heteroaralkyl group, and Z2 is selected from an unsubstituted or substituted aryl or heteroaryl, and an unsubstituted or substituted aralkyl or heteroaralkyl group; A is selected from H, C1-4 alkyl, C1-4 alkoxy, hydroxy, CH2(CH2)nOH (n=1-4), and NRa1Ra2 where Ra1 and Ra2 are each independently H or C1-4 alkyl; B is selected from H, halo, C1-4 alkyl, C1-4 alkoxy, CF3, an optionally substituted aryl or an optionally substituted aralkyl, and a hydroxy group that may undergo a C═O tautomeric rearrangement; and Y comprises an unsubstituted or substituted 4- to 8-membered carbocyclic or heterocyclic ring, optionally forming part of a larger fused ring structure, or consists of an optionally substituted linear or branched hydrocarbon chain. These purine derivatives are potential chemotherapeutic agents and, accordingly, the present invention also relates to the use of these compounds in the treatment of tumours or other cell proliferation disorders and pharmaceutical compositions comprising these compounds.
A purine compound having CDK-inhibiting activity useful for the treatment of tumours and other cell proliferation disorders in mammals, said compound having the structural formula I below:
A purine compound as claimed in any preceding claim, wherein Y comprises a ring structure that includes polar hydroxyl substituents.
A purine compound as claimed in any preceding claim, wherein Y is a cycloalkane or cycloalkene ring.
A purine compound as claimed in any preceding claim in which Y is a 5- or 6-membered cycloalkane or cycloalkene ring having one or two double bonds.
A purine compound as claimed in any preceding claim, wherein A is H, B is H and X is O.
A purine compound as claimed in any preceding claim, wherein said purine compound is further characterised by one of the following features:
A purine compound having a structural formula as shown below:
A purine compound wherein said compound in one of the following:
Dependencies are inferred from the claim text.