US 2004/0110772 A1 · Inhibitors of nucleoside phosphorylases and nucleosidases

Abstract

The invention provides a compound of the formula: 1 wherein A is selected from N, CH and CR; R is selected from halogen, optionally substituted alkyl, aralkyl and aryl, OH, NH2, NHR1, NR1R2 and SR3; R1, R2 and R3 are each optionally substituted alkyl, aralkyl or aryl groups; B is selected from NH2 and NHR4; R4 is an optionally substituted alkyl, aralkyl or aryl group; X is selected from H, OH and halogen; Z is selected from H, Q, SQ and OQ; Q is an optionally substituted alkyl, aralkyl or aryl group; or a tautomer, a pharmaceutically acceptable salt, an ester, or a prodrug thereof; with the proviso that the stereochemistry of the aza-sugar moiety is D-ribo or 2′-deoxy-D-erythro-; pharmaceutical compositions comprising said compound; and methods of treatment using said compound.

Claims31

Dependent claims

A compound of the formula (I):

54
wherein:
A is selected from N, CH and CR,
where R is selected from halogen, optionally substituted alkyl, aralkyl and aryl, OH, NH2, NHR1, NR1R2 and SR3,
where R1, R2 and R3 are each optionally substituted alkyl, aralkyl or aryl groups;
B is selected from NH2 and NHR4,
where R4 is an optionally substituted alkyl, aralkyl or aryl group;
X is selected from H, OH and halogen;
and
Z is selected from H, Q, SQ and OQ,
where Q is an optionally substituted alkyl, aralkyl or aryl group;
or a tautomer thereof;
or a pharmaceutically acceptable salt thereof;
or an ester thereof;
or a prodrug thereof;
with the proviso that the stereochemistry of the aza-sugar moiety is D-ribo or 2′-deoxy-D-erythro-.

13 more elements

Dependencies are inferred from the claim text.

Inhibitors of nucleoside phosphorylases and nucleosidases

Life of this patent

Inhibitors of nucleoside phosphorylases and nucleosidases

Life of this patent

Abstract

Claims31