3-(Pyridinyl-piperazin-1-yl)-phenylethyl amides as potassium channel openers
AssigneeBristol-Myers Squibb Company
InventorsYong-Jin Wu, Li-Qiang Sun, Jie Chen
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Abstract
The present invention provides piperazinyl phenylethyl amides and related derivatives having the general Formula I 1 wherein R1, R2, R3, R4, R5, R6, A and B are as defined in the specification, or a nontoxic pharmaceutically acceptable salt, solvate or hydrate thereof which are openers or activators of KCNQ potassium channels. The present invention also provides pharmaceutical compositions comprising said piperazinyl phenylethyl amides and to the method of treatment of disorders sensitive to KCNQ potassium channel opening activity such as migraine or a migraine attack, bipolar disorders, epilepsy, acute and chronic pain, and anxiety.
Claims8
A compound of Formula I or a pharmaceutically acceptable salt thereof
- 37
- wherein
- R1 is selected from the group consisting of pyridinyl, 3-quinolinyl, 2-thienyl, C3-6 cycloalkyl and phenyl optionally substituted with substituent independently selected from the group consisting of halogen, C1-4 alkyl, C1-4 alkoxy, trifluoromethyl and trifluoromethoxy;
- A is —CH═CH— or —(CH2)n—;
- R2 is C1-4 alkyl, CF3 or hydroxymethyl;
- R3, R4, R5 and R6 each are independently hydrogen or fluoro;
- n is an integer of 1 or 2;
- and
- B is 2-pyridinyl, 3-pyridinyl or 4-pyridinyl.
Dependencies are inferred from the claim text.