Flt-1 ligands and their uses in the treatment of diseases regulatable by angiogenesis

The use of a compound of formula:

• 18
• wherein
• W is an aromatic core selected from phenyl, pyridyl, pyrimidyl, oxadiazolyl, or triazyl,
• Ar is an aromatic substituent, which may be substituted or unsubstituted, where Ar is substituted, it preferably has up to three substituents, and preferably such substituents are in the meta or para position relative to the attachment of Ar to the core molecule, substituents are selected from amino, alkylamino, dialkylamino, loweralkoxy, nitro, carboxy, hydroxy, alkoxy alkyl, alkoxy alkoxy, alkylthio, haloalkyl, halo, lower alkyl, phenyl, pyridyl, an ester, or an amide,
• R1 is selected from,
• 19
• wherein
• A is a bond or a spacer selected from phenyl, substituted phenyl, amino, amido, ester, oxy, wherein when phenyl is the spacer, the phenyl spacer is attached to the molecule in the meta or para position,
• B is a linker selected from oxy, alkoxy, aryl carbonyl, arylcarbonylamino, a bond, amido, carbonyloxy, oxycarbonyl.
• V is an aryl group, selected from phenyl, furyl, thienyl, pyridyl, and pyrrolyl,
• X and Y are hydrogen, or together from oxo,
• Z is selected from among oxygen, nitrogen, and sulfur,
• R2 is selected from Ar, hydrogen, hydroxy, halo, carboxy or R1
• R3 is selected from one or two of hydroxy, alkoxy, nitro, sulfoxy, carboxyester, or an amide or such radicals connected to the substituent via a lower alkyl,
• R4 is one or two of amino, alkylamino, dialkylamino, loweralkoxy, nitro, carboxy, hydroxy, alkoxy alkyl, alkoxy alkoxy, alkylthio, haloalkyl, halo, lower alkyl, phenyl, pyridyl, an ester, or an amide, wherein at least one of R3 and R4 must be carboxy, or a carboxy substituted radical, and
• or pharmaceutically acceptable salt thereof, or a prodrug thereof, or a composition containing such compound, pharmaceutically acceptable salt or prodrug, for the treatment or prophylaxis of diseases by binding to the Flt-1 receptor.