Arylcyclopropylcarboxylic amides as potassium channel openers
AssigneeBristol-Myers Squibb Company
InventorsYong-Jin Wu, Li-Qiang Sun, Alexandre L'Heureux
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Abstract
The present invention provides novel arylcyclopropylcarboxylic amides and related derivatives having the general Formula I 1 wherein R, R1, R2, R3, R4, R5, R6 and R7 are as defined in the specification, or a nontoxic pharmaceutically acceptable salt, solvate or hydrate thereof which are openers or activators of KCNQ potassium channels. The present invention also provides pharmaceutical compositions comprising said arylcyclopropylcarboxylic amides and to the method of treatment of disorders sensitive to KCNQ potassium channel opening activity such as migraine or a migraine attack, bipolar disorders, epilepsy, acute and chronic pain and anxiety.
Claims8
A compound of Formula I or a pharmaceutically acceptable salt thereof
- 60
- wherein
- R is C1-4 alkyl, CF3 or hydroxymethyl;
- R1 and R2 are each independently hydrogen, C1-4 alkyl, halogen or morpholin-4-yl;
- R4 is selected from the group consisting of optionally substituted morpholin-4-yl, pyridinyl, pyrimidinyl, piperazinyl, and pyrazinyl, in which said substituent is independently selected from the group consisting of C1-4alkyl, dimethylamino, hydroxymethyl, chloro and fluoro;
- R5 is hydrogen or fluoro;
- or R4 and R5 taken together are —CH═CH—CH═CH— or —CH2CH2O—;
- and
- R3, R6 and R7 are each independently selected from hydrogen or fluoro.
Dependencies are inferred from the claim text.