Dihydrodiaryloxazepine derivative and pharmaceutical composition containing the same

5,11-Dihydrodiaryl[b,e][1,4]oxazepine derivatives represented by the following general formula [XV], stereoisomers thereof and salts thereof:

• 97
• wherein rings G, J and K each represent benzene ring or a nitrogen-containing aromatic ring;
• R1 R8 may be the same or different from one another and they each represent a halogen atom or a hydrogen atom, R9 to R13 may be the same or different from one another and they each represent a hydrogen atom, a halogen atom, cyano group, hy6droxyl group, a lower alkyl group, a lower alkoxyl group, amino group or a lower alkylamino group or a lower acylated derivative of such a group, a lower dialkylamino group or a cycloalkylamino group, or R9 and R10 or R10 and R11 together form —O(CH2)nO— group wherein n is 1, 2 or 3;
• L1 represents CH2, CHOH or O;
• L2 represents CH2, CHOH, CH2—CH2, CHOH—CH2, CH2—CH2—CH2 or CHOH—CH2—CH2;
• or L1 and L2 are bonded together to form CH2, CHOH or CH═CH, Y and Z are bonded together to form CH2—CH2—CH2 or CH2—CH2—CH2—CH2 or when Y and Z are not bonded together, Y represents a hydrogen atom and Z represents a lower alkyl group;
• provided that when any of R9 to R13 represents a cyclic amino group of the following formula [E], R1 to R8 may be a halogen atom or hydrogen atom but when none of R9 to R13 is a cyclic amino group of formula [E], one or two of R1 R8 represent a halogen atom and the others represent a hydrogen atom:
• 98
• wherein n and m each represent 1 or 2, and W represents carbon atom, or nitrogen which may be substituted with a lower alkyl group, or oxygen, or sulfur atom.

Amide derivatives of general formulae [XVI], stereoisomers thereof and salts thereof:

• 99
• wherein rings G, J and K each represent benzene ring or a nitrogen-containing aromatic ring;
• R1 to R8 may be the same or different from one another and they each represent a halogen atom or hydrogen atom, R9 to R13 may be the same or different from one another and they each represent a hydrogen atom, a halogen atom, cyano group, hydroxyl group, a lower alkyl group, a lower alkoxyl group, amino group or a lower alkylamino group or a lower acylated derivative of such a group, a lower dialkylamino group or a cycloalkylamino group, or R9 and R10 or R10 and R11 together form —O(CH2)nO— group wherein n is 1, 2 or 3;
• L1 represents CH2, CHOH or O;
• L2 represents CH2, CHOH, CH2—CH2, CHOH—CH2, CH2—CH2—CH2 or CHOH—CH2—CH2;
• or L1 and L2 are bonded together to form CH2, CHOH or CH═CH, Y and Z are bonded together to form CH2—CH2—CH2 or CH2—CH2—CH2—CH2 or wnen Y and Z are not bonded together, Y represents a hydrogen atom and Z represents a lower alkyl group;
• provided that when any of R9 to R13 represents a cyclic amino group of the following formula [E], R1 to R8 may be a halogen atom or hydrogen atom but when none of R9 to R13 is a cyclic amino group of formula [E], one or two of R1 to R8 represent a halogen atom and the others represent a hydrogen atom:
• 100
• wherein n and m each represent 1 or 2, and W represents carbon atom, or nitrogen which may be substituted with a lower alkyl group, or oxygen, or sulfur atom.