Combinations for the treatment of inflammatory disorders

A composition formulated for topical administration, said composition comprising a tricyclic antidepressant and a corticosteroid in amounts that, when administered together to a patient having an immunoinflammatory disorder, inhibit or reduce inflammation or otherwise treat said disorder, wherein said tricyclic antidepressant is selected from the group consisting of maprotiline, amoxapine, 8-hydroxyamoxapine, 7-hydroxyamoxapine, loxapine, 8-hydroxyloxapine, clomipramine, desipramine, imipramine, trimipramine, nortriptyline, and protriptyline.

A composition formulated for inhalation administration, said composition comprising a tricyclic antidepressant and a corticosteroid in amounts that, when administered together to a patient having an immunoinflammatory disorder, inhibit or reduce inflammation or otherwise treat said disorder.

A method for treating an immunoinflammatory disorder in patient in need thereof, said method comprising administering to said patient a tricyclic antidepressant and a low dose corticosteroid, wherein the tricyclic antidepressant and the corticosteroid are administered simultaneously, or within 14 days of each other, in amounts that together are sufficient to treat said disorder.

A method for treating an immunoinflammatory disorder selected from psoriasis, ulcerative colitis, Crohn's disease, stroke-induced brain cell death, ankylosing spondylitis, fibromyalgia, asthma, multiple sclerosis, type I diabetes, systemic lupus erythematosus, scleroderma, systemic sclerosis, and Sjögren's syndrome in a patient in need thereof, said method comprising administering to said patient a tricyclic antidepressant and a corticosteroid, wherein said tricyclic antidepressant is selected from the group consisting of maprotiline, amoxapine, 8-hydroxyamoxapine, 7-hydroxyamoxapine, loxapine, 8-hydroxyloxapine, amitriptyline, desipramine, clomipramine, doxepin, imipramine, trimipramine, nortriptyline, and protriptyline;

• wherein the tricyclic antidepressant and the corticosteroid are administered simultaneously, or within 14 days of each other, in amounts that together are sufficient to treat said disorder.

A method for treating rheumatoid arthritis in a patient in need thereof, said method comprising administering to said patient a tricyclic antidepressant and a corticosteroid, wherein said tricyclic antidepressant is selected from the group consisting of maprotiline, amoxapine, 8-hydroxyamoxapine, 7-hydroxyamoxapine, loxapine, 8-hydroxyloxapine, clomipramine, doxepin, imipramine, trimipramine, nortriptyline, and protriptyline;

• wherein the tricyclic antidepressant and the corticosteroid are administered simultaneously, or within 14 days of each other, in amounts that together are sufficient to treat said rheumatoid arthritis.

A method for treating an immunoinflammatory disorder in patient in need thereof, said method comprising administering to said patient a tricyclic antidepressant selected from the group consisting of maprotiline, amoxapine, 8-hydroxyamoxapine, 7-hydroxyamoxapine, loxapine, 8-hydroxyloxapine, clomipramine, desipramine, imipramine, trimipramine, nortriptyline, amitriptyline, and protriptyline, and a corticosteroid, wherein said tricyclic antidepressant and the corticosteroid are administered simultaneously or within 14 days of each other in amounts that together are sufficient to treat said disorder and said tricyclic antidepressant is topically administered to said patient.

A method for treating an immunoinflammatory disorder selected from rheumatoid arthritis, psoriasis, ulcerative colitis, Crohn's disease, stroke-induced brain cell death, ankylosing spondylitis, fibromyalgia, asthma, multiple sclerosis, type I diabetes, systemic lupus erythematosus, scleroderma, systemic sclerosis, and Sjögren's syndrome, said method comprising administering to a patient a tricyclic antidepressant and a corticosteroid, wherein said tricyclic antidepressant and the corticosteroid are administered simultaneously or within 14 days of each other in amounts that together are sufficient to treat said disorder and said tricyclic antidepressant is topically administered to said patient.

A method for treating an immunoinflammatory disorder in a patient in need thereof, said method comprising administering to said patient a tricyclic antidepressant and a corticosteroid, wherein said tricyclic antidepressant and the corticosteroid are administered simultaneously or within 14 days of each other in amounts that together are sufficient to treat said disorder and said tricyclic antidepressant is administered by inhalation to said patient.