Photodynamic therapy for the treatment of non-melanoma skin cancer
OwnerAgnes H. Chan, Herma C. Neyndorffinventors
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Abstract
The present invention relates to a method of treating non-melanoma skin cancer comprising: (a) intravenously administering a porphyrin based photosensitizer to a subject with non-melanoma skin cancer; (b) irradiating one or more tumors and a circumferential peritumoral margin of at least 1 mm with a light at a wavelength absorbed by said photosensitzer; wherein the irradiating step delivers a light dose of 180 J/cm2. It has been found that the above treatment gives extremely good efficacy while having a surprisingly good cosmetic outcome.
Claims21
A method of treating non-melanoma skin cancer comprising:
- (a) intravenously administering benzoporphyrin derivative monoacid A ring to a subject with non-melanoma skin cancers;
- (b) irradiating one or more tumors and a circumferential peritumoral margin of 1-8 mm with a light at a wavelength of 688 nm (±10 nm);
- wherein the irradiating step delivers a light dose of 180 J/cm2 (±36 J/cm2).
A method of treating non-melanoma skin cancer comprising:
- (a) intravenously administering verteporfin to a subject non-melanoma skin cancers;
- (b) irradiating one or more tumors and a circumferential peritumoral margin of 1-8 mm with a light at a wavelength of 688 nm (±10 nm);
- wherein the irradiating step delivers a light dose of 180 J/cm2 (±36 J/cm2).
4 A method according to claim 1 wherein the non-melanoma skin cancer is multiple basal cell carcinoma.
An article comprising:
- (a) verteporfin, and
- (b) instructions for the use of the verteporfin for treating non-melanoma skin cancer by intravenously administering the verteporfin to a subject with non-melanoma skin cancers, and, after at least 1 hour but not more the 3 hours from the start of infusion, irradiating one or more tumor and a circumferential peritumoral margin of 3-4 mm with a light dose of 180 J/cm2 (±36 J/cm2) said light being of a wavelength of 688 nm (±10 nm).
Dependencies are inferred from the claim text.