Primary N-hydroxylamines
OwnerBruce N. Ames, Hani Atamnainventors
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Abstract
The invention provides pharmaceutical compositions comprising primary N-hydroxylamines and related therapeutic, prophylactic, diagnostic and screening methods. The pharmaceutical compositions generally comprise a pharmaceutical composition comprising an orally administrable effective unit solid dosage of a primary N-hydroxylamine or a pharmaceutically acceptable salt thereof and substantially free of a nitrone corresponding to the hydroxylamine.
Claims58
A pharmaceutical composition for reducing oxidative damage or delaying senescence comprising an orally administrable effective unit dosage of a primary N-hydroxylamine or a pharmaceutically acceptable salt thereof and substantially free of a nitrone corresponding to the hydroxylamine, wherein the hydroxylamine has the general formula,
- NHOHCR1R2R3,
- wherein R1, R2 and R3 are independently selected from:
- hydrogen, substituted or unsubstituted (C1-C10) alkyl, alkenyl, alkynyl, aryl, oxyl, acyl, carboxyl, amino, nitro, nitroso, oxime, hydrazone, azo, thiol, sulfonyl and halide.
A composition according to claim l, wherein at least one R of R1, R2 and R3 is substituted or unsubstituted (C1-C18) oxime and the R is selected from:
- acetaldoxime, propionaldoxime, butanaldoxime and benzaldoxime.
Dependencies are inferred from the claim text.