Modified hyaluronic acid polymers
OwnerRichard L. Ornberg, Kishore Udipi +6inventors
InventorsRichard L. Ornberg, Kishore Udipi, Denis Forster, Dennis P. Riley, Kenneth B. Thurmond, Susan Henke, Kerry Brethauer, Saikat Joardar
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Abstract
The present invention relates to hyaluronic acid polymers modified with non-proteinaceous catalysts for the dismutation of superoxide, and processes for making such materials. The invention further provides pharmaceutical compositions comprising the modified biopolymer and therapeutic methods comprising administering the modified biopolymer to a subject in need thereof.
Claims20
A modified hylauronic acid polymer comprising hyaluronic acid bound to at least one non-proteinaceous catalyst capapble of dismutating superoxide in the biological system or precursor ligand thereof, wherein the modified hyaluronic acid polymer exhibits a lower molecular weight by size exclusion chromatography than unmodified hyaluronic acid.
Dependencies are inferred from the claim text.