Pharmaceutical compositions for promoting the growth of gram-positive bacilli and increasing the acidity in the vagina and the use thereof

A method for treating a patient suffering from vaginitis, a disturbance of the vaginal bacterial flora or bacterial vaginosis, wherein said vaginitis, disturbance of the vaginal bacterial flora or bacterial vaginosis are accompanied with a reduction of the number of Gram-positive bacilli, said method comprising vaginally administering to a subject in need of such treatment a therapeutically effective amount of a composition comprising:

• (a) Sucrose and/or maltose in a concentration of from about 2.5% to about 17% w/v based on the total volume of the composition,
• (b) An anti-fungal drug in a concentration of from about 0.0001% to about 5% w/v based on the total volume of the composition, and
• (c) A sufficient amount of a pharmaceutically acceptable acid or alkali, which results in a pH of the composition from about 4.1 to about 7.2;
• wherein said administration promotes selective growth of gram-positive bacilli in the vagina of said subject.

A method for treating a patient suffering from vaginitis, a disturbance of the vaginal bacterial flora or bacterial vaginosis, wherein said vaginitis, disturbance of the vaginal bacterial flora or bacterial vaginosis are accompanied with a reduction of the number of Gram-positive bacilli, said method comprising, simultaneously or sequentially, vaginally administering to a subject in need of such treatment a therapeutically effective amount of composition (A) and composition (B), wherein

• Composition (A) comprises:
• (a) Sucrose and/or maltose in a concentration of from about 2.5% to about 17% w/v based on the total volume of the composition, and
• (b) A sufficient amount of a pharmaceutically acceptable acid or alkali, which results in a pH of the composition from about 4.1 to about 7.2;
• and
• Composition (B) comprises:
• (a) An anti-fungal drug in a concentration of from about 0.0001% to about 5% w/v based on the total volume of the composition, and
• (b) A sufficient amount of a pharmaceutically acceptable acid or alkali, which results in a pH of the composition from about 4.1 to about 7.2.