Methods for treating patients and identifying therapeutics
OwnerSanford D. Markowitzinventor
Life of this patent
Estimating the term…
Abstract
The disclosure provides, among other things, molecular markers for categorizing the neoplastic state of a patient, methods for using the molecular markers in designing, screening for and targeting.
Claims27
A method for inhibiting the growth or proliferation of a colon neoplasia in a subject, the method comprising administering to the subject an agent that decreases the amount of a polypeptide present in or produced by the colon neoplasia, said polypeptide selected from among:
- ColoUp1, ColoUp2, ColoUp3, ColoUp4, ColoUp5, ColoUp6, ColoUp7 and ColoUp8.
A method for inhibiting the growth or proliferation of a cell of a colon neoplasia in a subject, the method comprising administering to the subject an agent that binds to and antagonizes a polypeptide selected from among:
- ColoUp1, ColoUp2, ColoUp3, ColoUp4, ColoUp5, ColoUp6, ColoUp7 and ColoUp8.
A therapeutic agent that is targeted to a colon neoplasia, the agent comprising a targeting moiety and an active moiety, wherein the targeting moiety binds to a polypeptide selected from among ColoUp1, ColoUp2, ColoUp3, ColoUp4, ColoUp5, ColoUp6, ColoUp7 and ColoUp8 and wherein the active moiety facilitates the killing or growth inhibition of a cell of a colon neoplasia.
A method of identifying a candidate agent for treating colon cancer, the method comprising:
- identifying a candidate agent that binds to and/or inhibits an activity of a polypeptide selected from among:
- ColoUp1, ColoUp2, ColoUp3, ColoUp4, ColoUp5, ColoUp6, ColoUp7 and ColoUp8.
Dependencies are inferred from the claim text.