Method of treating neurological diseases
OwnerMalcom Maden, Jonathan Patrick Thomas Corcoraninventors
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Abstract
The invention relates to a method of treating a condition in a subject comprising administering an effective amount of an agent to said subject wherein said agent modulates one or more components of the retinoid signaling pathway.
Claims26
A method for treating a condition in a subject comprising administering an effective amount of an agent to said subject wherein said agent modulates one or more component(s) of the retinoid signalling pathway.
A method for treating a condition in a subject comprising administering an effective amount of an agent to a subject wherein said agent modulates the expression of one or more component(s) of the retinoid signalling pathway.
A method according to any preceding claim wherein said agent comprises raldh-2.
A pharmaceutical composition comprising a RALDH-2 polypeptide, or a fragment, variant or derivative thereof, or a polynucleotide encoding same, and a pharmaceutically acceptable carrier, diluent or excipient therefor.
Use of a RALDH-2 polypeptide, or a fragment, variant or derivative thereof, or a polynucleotide encoding same, in the manufacture of a medicament for treatment of a neurological condition.
A gene therapy vector comprising a retinoid receptor gene or a fragment, variant or derivative thereof.
A gene therapy vector comprising an aldehyde dehydrogenase gene or a fragment, variant or derivative thereof.
A gene therapy vector comprising a retinoic acid responsive gene or a fragment, variant or derivative thereof.
A gene therapy vector comprising the mouse or human raldh-2 gene or a fragment, variant or derivative thereof.
Dependencies are inferred from the claim text.